Molecular neuropharmacology : strategies and methods

著者

書誌事項

Molecular neuropharmacology : strategies and methods

edited by Arne Schousboe and Hans Bräuner-Osborne

Humana Press, c2004

  • alk. paper

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.

目次

Part I. Molecular Pharmacology of Glutamate Receptors Computational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate Receptors Jeremy R. Greenwood and Tommy Liljefors Delineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective Ligands Sari E. Lauri, Vernon R. J. Clarke, and Graham L. Collingridge Molecular Pharmacology of the Metabotropic Glutamate Receptors Anders A. Jensen Part II. Molecular Pharmacology of Gaba Receptors Functional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo Activity Bjarke Ebert, Sally Anne Thompson, Signe I Storustovu, and Keith A. Wafford In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice Jean-Marc Fritschy Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling Bente Froland, Anne T. Jorgensen, Tommy Liljefors, Martin Mortensen, and Povl Krogsgaard-Larsen The GABAB Receptor: From Cloning to Knockout Mice Bernhard Bettler and Hans Brauner-Osborne Part III. Molecular Pharmacology of Transmitter Transporters Structure and Molecular Characterization of the Substrate-Binding Sites of the Dual-Function Glutamate Transporters Baruch I. Kanner, Michael P. Kavanaugh, and Lars Borre Allosteric Modulation of Glutamate Transporters Robert J. Vandenberg and Renae M. Ryan Characterization of the Substrate-Binding Site in GABA Transporters Alan Sarup, Orla Miller Larsson, and Arne Schousboe Insights From Endogenous and Engineered Zn21 Binding Sites in Monoamine Transporters Claus Juul Loland and Ulrik Gether A Structural Context for Studying Neurotransmitter Transporter Function Naomi R. Goldberg, Thijs Beuming, Harel Weinstein, and Jonathan A. Javitch Functional Mechanisms of GProtein-Coupled Receptors in a Structural Context Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne, and Harel Weinstein Index

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