Chemogenomics in drug discovery : a medicinal chemistry perspective
著者
書誌事項
Chemogenomics in drug discovery : a medicinal chemistry perspective
(Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], v. 22)
Wiley-VCH, c2004
- : hbk
大学図書館所蔵 全5件
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and from leading pharmaceutical companies, this book is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
目次
Preface. A Personal Foreword. List of Contributors. Introduction (G. Muller & H. Kubinyi). I: GENERAL ASPECTS. 1. Target Family-directed Masterkeys in Chemogenomics (G. Muller). 2. Drug Discovery from Side Effects (H. Kubinyi). 3. The Value of Chemical Genetics in Drug Discovery (K. Russell & W. Michne). 4. Structural Aspects of Binding Site Similarity: A 3D Upgrade for Chemogenomics (A. Bergner & J. Gunther). II: TARGET FAMILIES. 5. The Contribution of Molecular Informatics to Chemogenomics: Knowledge-based Discovery of Biological Targets and Chemical Lead Compounds (E. Jacoby, et al.). 6. Chemical Kinomics (B. Klebl, et al.). 7. Structural Aspects of Kinases and Their Inhibitors (R. Buijsman). 8. A Chemical Genomics Approach for Ion Channel Modulators (K. Baringhaus & G. Hessler). 9. Phosphodiesterase Inhibitors: A Chemogenomic View (M. Hendrix & C. Kallus). 10. Proteochemometrics: A Tool for Modeling the Molecular Interaction Space (J. Wikberg, et al.). III: CHEMICAL LIBRARIES. 11. Some Principles Related to Chemogenomics in Compound Library and Template Design for GPCRs (T. Webb). 12. Computational Filters in Lead Generation: Targeting Drug-like Chemotypes (W. Guba & O. Roche). 13. Navigation in Chemical Space: Ligand-based Design of Focused Compound Libraries (G. Schneider & P. Schneider). 14. Natural Product-derived Combinatorial Libraries and Protein Structure Similarity as Guiding Principles for the Discovery of Drug Candidates (M. Koch & H. Waldmann). 15. Combinatorial Chemistry in the Age of Chemical Genomics (R. Joseph & P. Arya). Index.
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