Nuclear organization in development and disease
Author(s)
Bibliographic Information
Nuclear organization in development and disease
(Novartis Foundation symposium, 264)
John Wiley & Sons, c2005
Available at 7 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
-
National Institutes of Natural Sciences Okazaki Library and Information Center図
463.4/Nu9509108621
Note
Includes bibliographical references and index
Description and Table of Contents
Description
This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include:
How nuclear structure and location within a nucleus affect gene expression
Chromatin organization and cell differentiation
The nature of the interactions between the nuclear envelope and the cytoskeleton
The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes
It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.
Table of Contents
Chair's Introduction (R. Goldman). Nuclear lamins: building blocks of nuclear structure and function (R. Goldman, et al.).
Aspects of nuclear envelope dynamics in mitotic cells (B. Burke, et al.).
Components of the nuclear envelope and their role in human disease (H. Worman).
Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease (K. Wilson, et al.).
Identification of novel integral membrane proteins of the nuclear envelope with potential disease links using subtractive proteomics (E. Schirmer, et al.).
Genetics of laminopathies (R. Ben Yaou, et al.).
Muscular dystrophies related to the cytoskeleton/nuclear envelope (K. Nowak, et al.).
Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss muscular dystrophy (M. Grattan, et al.).
Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for Sir-mediated repression (A. Taddei, et al.).
A-type lamin-linked lipodystrophies (C. Vigouroux and J. Capeau).
Cytoskeletal defects in amyotrophic lateral sclerosis (motor neuron disease) (J. Julien, et al.).
LMNA mutations in progeroid syndromes (S. Huang, et al.).
A genetic approach to study the role of nuclear envelope components in nuclear positioning (D. Starr and M. Han).
General Discussion I.
A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development (A. Margalit, et al.).
Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy (S. Kozlov, et al.).
The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C-deficient cells (J. Lammerding and R. Lee).
Chair's summing up (R. Goldman).
Index of contributors.
Subject index.
by "Nielsen BookData"