Molecular mechanisms of atherosclerosis
著者
書誌事項
Molecular mechanisms of atherosclerosis
Taylor & Francis, 2005
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world. Written by notable authorities and providing text rich in illustrative figures, Molecular Mechanisms in Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineates current views of the molecular and cellular basis of the process. The editor approaches the issue from a mechanistic perspective, and does so in the context of contemporary knowledge of molecular and cellular pathobiology.
The book provides an epidemiological overview of atherosclerotic vascular disease, followed by a review of the genetics and genetic epidemiology. It focuses on the four fundamental mechanisms common to all risk factors for atherosclerosis: inflammation, oxidative stress, thrombosis, and endothelial dysfunction and the mechanisms under lying for common risk factors for atherogenesis: dyslipidaemias, diabetes mellitus, hypertension, and smoking. The book then discusses the recently proposed risk factors hyperhomocysteinemia and infection and rational molecular therapies to prevent and combat established atherothrombotic disease.
Taken together, these chapters offer a broad review of the molecular and cellular mechanisms of atherothrombogenesis. The topics covered and the order of presentation were carefully chosen to clarify the complexity of the disease process. Armed with the information contained in this text, you can confidently explore cutting-edge research with insight and foresight regarding their implications for prevention and treatment.
目次
Introduction and Overview, J. Loscalzo
Epidemiology of Atherosclerotic Disease, P.W.F. Wilson
Genetics of Atherothrombosis in Humans, D.F. Wyszynski and L.A. Farrer
Inflammation and Atherosclerosis, F.L. Ruberg and J. Loscalzo
Oxidative Stress and Atherosclerosis, R. Stocker and J.F. Keaney, Jr.
Thrombosis and Atherosclerosis, J.E. Freedman and J. Loscalzo
Endothelial Dysfunction in Atherosclerosis: Mechanisms of Impaired Nitric Oxide Bioactivity, N.M. Hamburg and J.A. Vita
Lipoproteins and Atherogenesis, V.I. Zannis, K. Kypreos, A. Chroni, D. Kardassis, and E.E. Zanni
Diabetes Mellitus as an Atherogenetic Factor, C. Panzer, Y. Ido, and N. Ruderman
Hypertension and Atherogenesis, D.E. Handy and H. Gavras
Smoking and the Molecular Mechanisms of Atherosclerosis, A. Kadar and A. Spira
Homocysteine and Atherogenesis, D.E. Handy and J. Loscalzo
Infection and Atherogenesis, C. Attardo Genco and F.C. Gibson, III
Rational Contemporary Molecular and Cell-Based Therapies, J.A. Leopold and J. Loscalzo
Future Directions, J. Loscalzo
Index
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