Cancer gene therapy
著者
書誌事項
Cancer gene therapy
(Contemporary cancer research / Jac A. Nickoloff, series editor)
Humana Press, c2005
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
目次
Cancer Gene Therapy: Historical Perspective
Malcolm K. Brenner
The Genetic Basis of Cancer
Akseli Hemminki and Kari Hemminki
Tumor Suppressor Gene Replacement for Cancer
Jack A. Roth and Susan F. Grammer
Antisense Technology
Ruiwen Zhang and Hui Wang
Cancer Therapeutic Applications of Ribozymes and RNAi
Lisa Scherer and John J. Rossi.
Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy: A Better Class of Killer
Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, and Richard Vile
Suicide Gene Therapy
Caroline J. Springer and Ion Niculescu-Duvaz
Molecular Chemotherapy Approaches
Daniel H. Palmer and David J. Kerr
Genetic Immunotherapy Approaches
Denise R. Shaw and Albert F. LoBuglio
Immunotherapy of Cancer By Dendritic Cell-Targeted Gene Transfer
Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper.
Dendritic Cells
Weiping Zou, Shuang Wei, and Tyler J. Curiel
Polynucleotide Immunization for Cancer Therapy
Theresa V. Strong
Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors: The G207 Paradigm
Tomoki Todo and Samuel D. Rabkin
Development of Oncolytic Adenoviruses: From the Lab Bench to the Bedside
John A. Howe, Robert Ralston, and Murali Ramachandra
Conditionally Replicating Adenoviruses for Cancer Treatment
Ramon Alemany
Reovirus as an Oncolytic Agent
Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee
Antiangiogenic Gene Therapy of Cancer
Steve Gyorffy, Jack Gauldie, A. Keith Stewart, and Xiao-Yan Wen
Proapoptotic Strategy in Cancer Gene Therapy
David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, and James S. Norris
Antimetastasis
Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung
Antimetastatic Gene Therapy: Prostate Cancer Theory to Therapy
Thomas A. Gardner, Juan Antonio Jimenez, Leland W. K. Chung, and Chinghai Kao
Drug Resistance Gene Transfer as an Antitumor Strategy
Colin L. Sweeney and R. Scott McIvor
Chemosensitization
Per Eystein Lonning
Radiosensitization by Gene Therapy
Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum
Nonviral Vector Systems for Cancer Gene Therapy
Greg F. Walker and Ernst Wagner
Viral Vectors for Cancer Gene Therapy
Joanne T. Douglas and David T. Curiel
Bacterial Systems for Tumor-Specific Gene Therapy
J. Martin Brown, Shie-Chau Liu, Jan Theys, and Philippe Lambin
Molecular Imaging of Cancer Gene Therapy
Harvey R. Herschman
Cancer-Related Gene Therapy Clinical Trials
Robert J. Korst and Ronald G. Crystal
Regulatory Aspects in the Development of Gene Therapies
Rosemarie Aurigemma, Joseph E. Tomaszewski, Sheryl Ruppel, Stephen Creekmore, and Edward A. Sausville
Index
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