Models of viral hepatitis
Author(s)
Bibliographic Information
Models of viral hepatitis
（Monographs in virology, v. 25）
Karger, c2005
- hard cover
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Viral hepatitis B or C is the most common cause of chronic liver disease worldwide and accounts for about 80% of all hepatocellular carcinoma cases. Thus, combating viral hepatitis remains one of the most pressing public health issues today. Animal models and cell-based systems are essential tools for addressing the many still unresolved basic and clinical problems. Experimental models are needed to better understand the viral life cycles, pathogenetic aspects and natural defense mechanisms, while preclinical models are required for evaluating novel preemptive and therapeutic strategies. This monograph provides a unique synopsis of currently available models of viral hepatitis, highlighting their particular use for basic and translational science. Leading experts discuss new scientific results and evolving methods in various animal and in vitro models, including the woodchuck, duck, mouse, chimpanzee and tupaia, as well as primary hepatocytes and subgenomic HCV replicons. A valuable single source of information, this book will be of interest to all investigators and clinicians working in the fields of viral hepatitis and/or hepatology.
Table of Contents
- Foreword: von Weizsacker, F.
- Roggendorf, M. The Woodchuck: A Model for Immunopathogenesis and Therapy of Hepadnaviral Infection: Roggendorf, M.
- Lu, M. Pathogenesis of Hepatitis B Virus in Transgenic Mice: Sitia, G.
- Iannacone, M.
- Chisari, F.V.
- Guidotti, L.G. Transfer of HBV Genomes into Mice: Oberwinkler, H.
- Untergasser, A.
- Sprinzl, M.
- Protzer, U. Recent Advances in the Duck Hepatitis B Virus Model: Jilbert, A.R. Determinants of Hepadnaviral Species and Liver Cell Tropism: Funk, A.
- Lin, L.
- Mhamdi, M.
- Will, H.
- Sirma, H. T-Cell Response to Hepatitis B and C Virus: Lessons from the Chimpanzee Model: Thimme, R.
- Bukh, J.
- Spangenberg, H.C.
- Wieland, S.F.
- Blum, H.E.
- Purcell, R.H.
- Chisari, F.V. The Replicon System as an Efficient Tool to Study HCV RNA Replication: Lohmann, V. Hepatitis B Virus Infection of Primary Tupaia Hepatocytes: Kock, J.
- Glebe, D. Tupaia belangeri as a Model for Hepatitis C Virus Infection: Baumert, T.F.
- Barth, H.
- Zhao, X.
- Schurmann, P., Tang, Z.-Y.
- Adah, M.I.
- Blum, H.E.
- von Weizsacker, F. Primary Human Hepatocytes as an in vitro Model for Hepatitis B Virus Infection: Boehm, S.
- Thasler, W.E.
- Weiss, T.S.
- Jilg, W. Progress and Perspectives of the uPA/RAG-2 Mouse Model: Liver Repopulation and Viral Infection Studies: Dandri, M.
- Burda, M.R.
- Matschl, U.
- Wursthorn, K.
- Petersen, J. The Trimera Mouse Model of HBV and HCV Infection: Bocher, W.O.
- Reisner, Y.
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