Drug tranport(ers) and the diseased brain : proceedings of the Esteve Foundation Symposium 11, held between 6 and 9 October 2004, S'Agaró (Girona), Spain
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書誌事項
Drug tranport(ers) and the diseased brain : proceedings of the Esteve Foundation Symposium 11, held between 6 and 9 October 2004, S'Agaró (Girona), Spain
(International congress series, no. 1277)
Elsevier, c2005
- タイトル別名
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Drug tranport
Drug tranporters and the diseased brain
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and indexes
内容説明・目次
内容説明
There are many potent drugs available for many diseases of the brain (e.g. Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Stroke, Brain tumours). The effectiveness, however, is not optimal since barriers in the brain prevent the drugs from reaching the brain in sufficient therapeutic concentrations (e.g. the blood-brain barrier and the blood-cerebrospinal fluid barrier). "Drug Transport(ers) and the Diseased Brain" contains the papers of a timely symposium held in Spain between 6 and 9 October 2004, which sets out not only the point of view of the academic researcher and the clinician, but also from the pharmaceutical industrial on how to overcome these barriers and how to treat brain diseases effectively.
目次
About the Esteve Foundation. Disclaimer. Group photo. Introduction and Acknowledgements. List of participants. Preface. The conditions for considering drug transport/targeting to the brain. Physiology of the blood-brain barrier and its consequences for drug transport to the brain (N.J. Abbott). The blood-brain barrier and treatment of lysosomal storage diseases (J.M. Aerts et al.). The priorities/needs of the pharmaceutical industry in drug delivery to the brain (M. Lemaire, S. Desrayaud). Influx transporters and drug targeting. Drug and gene targeting to the brain via blood-brain barrier receptor-mediated transport systems (W.M. Pardridge). Carrier-mediated transport to enhance drug delivery to brain (Q.R. Smith). Influx transporters and drug targeting: Application of peptide and cation transporters (A. Tsuji). Application of nanoparticles for the delivery of drugs to the brain (J. Kreuter). Application, efficiency and cargo-dependence of transport peptides (J.P.M. Langedijk, T. Olijhoek, R.H. Meloen). Efflux transporters at BBB. Efflux transport systems at the blood-brain barrier and blood CSF barrier (H. Kusuhara, Y. Sugiyama). Experimental models to evaluate the role of P-glycoprotein in the blood-brain tumor barrier (O. van Tellingen, E.M. Kemper, T. Buckle). Overcoming MDR at the blood-brain barrier (G. Fricker). Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by RNA interference (H. Lage). The multidrug resistance protein BMDP/ABCG2: A new and highly relevant efflux pump at the blood-brain barrier (A. Drees et al.). Additional approaches for drug delivery/targeting to the BBB/brain. Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier (R. Gabathuler et al.). Diphtheria toxin receptor-targeted brain drug delivery (P.J. Gaillard, A. Brink, A.G. de Boer). The use of Pep: Trans vectors for the delivery of drugs into the central nervous system (J.-M. Scherrmann, J. Temsamani). Single domain antibodies as blood-brain barrier delivery vectors (A. Abulrob et al.). The BBB as a drug target from the clinical point of view. The blood-brain barrier in trauma, stroke and edema (J. Verlooy, J. Van Reempts). The blood-brain barrier in multiple sclerosis (S. McQuaid, J. Kirk). The blood-brain barrier in diabetes mellitus: A critical review of clinical and experimental findings (E. Tolia et al.). Final discussion (A.G. de Boer). Novel opportunities for the treatment of brain diseases (A.G. de Boer). Author index. Keyword index.
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