Neurodegenerative diseases : neurobiology, pathogenesis, and therapeutics
著者
書誌事項
Neurodegenerative diseases : neurobiology, pathogenesis, and therapeutics
Cambridge University Press, 2005.
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注記
Includes bibliographical references and index.
内容説明・目次
内容説明
Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.
目次
- Part I. Basic Aspects of Neurodegeneration: 1. Endogenous free radicals and antioxidants in the brain
- 2. Biological oxidants and therapeutic antioxidants
- 3. Mitochondria, metabolic inhibitors and neurodegeneration
- 4. Excitotoxicity and excitatory amino acid antagonists in chronic neurodegenerative diseases
- 5. Glutamate transporters
- 6. Calcium binding proteins in selective vulnerability of motor neurons
- 7. Apoptosis in neurodegenerative diseases
- 8. Neurotrophic factors
- 9. Protein misfolding and cellular defence mechanisms in neurodegenerative diseases
- 10. Neurodegenerative disease and the repair of oxidatively damaged DNA
- 11. Compounds acting on ion channels
- 12. The role of nitric oxide and PARP in neuronal cell death
- 13. Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis
- 14. The role of inflammation in Alzheimer's disease neuropathology and clinical dementia: from epidemiology to treatment
- 15. 15. Selected genetically engineered models relevant to human neurodegenerative disease
- 16. Toxic animal models
- 17. A genetic outline of the pathways to cell death in Alzheimer's disease, Parkinson's disease, frontal dementias and related disorders
- 18. Neurophysiology of Parkinson's disease, levodopa-induced dyskinesias, dystonia, Huntington's disease and Myoclonus
- Part II. Neuroimaging in Neurodegeneration: 19. Structural and functional magnetic resonance imaging in neurodegenerative diseases
- 20. PET/SPECT
- 21. Magnetic resonance spectroscopy of neurodegenerative illness
- Part III. Therapeutic Approaches in Neurodegeneration: 22. Gene therapy
- 23. Stem cells and cell-based therapy in neurodegenerative disease
- 24. Necessary methodological and stem cell advances for restoration of the dopaminergic system in Parkinson's disease patients
- Part IV. Normal Aging: 25. Clinical aspects of normal aging
- 26. Neuropathology of normal aging in cerebral cortex
- Part V. Alzheimer's Disease: 27. Mild cognitive impairment
- 28. Alzheimer's disease - overview
- 29. The neuropathology of Alzheimer's disease in the year 2005
- 30. Genetics of Alzheimer's disease
- 31. The role of Beta-amyloid in Alzheimer's disease
- 32. Treatment of Alzheimer's disease
- Part VI. Other Dementias: 33. Dementia with Lewy bodies
- 34. Frontotemporal lobar degeneration
- 35. Frontotemporal dementia with Parkinsonism linked to Chromosome 17
- 36. Prion diseases
- Part VII. Parkinson's and Related Movement Disorders: 37. Approach to the patient presenting with Parkinsonism
- 38. Parkinson's disease
- 39. Neuropathology of Parkinson's disease
- 40. Genetics of Parkinsonism
- 41. Pathophysiology - biochemistry of Parkinson's disease
- 42. Current and potential treatments of Parkinson's disease
- 43. Multiple system atrophy
- 44. Progressive supranuclear palsy
- 45. Corticobasal degeneration
- Part VIII. Cerebellar Degenerations: 46. Approach to the patient with ataxia
- 47. Autosomal dominant cerebellar ataxia
- 48. Friedreich's ataxia and other autosomal recessive ataxias
- 49. Ataxia telangiectasia
- Part IX. Motor Neuron Diseases: 50. An approach to the patient with motor neuron dysfunction
- 51. The genetics of amyotrophic lateral sclerosis
- 52. Current and potential therapeutics in motor neuron diseases
- 53. The hereditary spastic paraplegias
- 54. Spinal and Bulbar muscular atrophy (Kennedy's disease)
- 55. Spinal muscular atrophies
- 56. Western Pacific ALS/Parkinsonism-Dementia complex
- Part X. Other Neurodegenerative Diseases: 57. Huntington's disease
- 58. Dentatorubral-pallidoluysian atrophy (DRPLA): model for Huntington's disease and other polyglutamine diseases
- 59. Neuroacanthocytosis
- 60. Brain iron disorders
- 61. Neurological aspects of Wilson's disease
- 62. Disorders of the mitochondrial respiratory chain
- Index.
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