The adrenergic receptors : in the 21st century

著者

    • Perez, Dianne M.

書誌事項

The adrenergic receptors : in the 21st century

edited by Dianne M. Perez

（Receptors）

Humana Press, c2006

大学図書館所蔵 件 / 全7件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

目次

Part I: Historical Perspectives Adrenergic Receptors: Historical Perspectives From the 20th Century David B. Bylund Part II: Structure-Function Ligand Binding, Activation, and Agonist Trafficking Angela M. Finch, Valerie Sarramegna, and Robert M. Graham New Signal Transduction Paradigms Kenneth P. Minneman Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors Michael T. Piascik, Mary Lolis Garcia-Cazarin, and Steven R. Post Adrenergic Receptors in Clinical Medicine Martin C. Michel and Paul A. Insel Part III: Imaging Adrenergic Receptors and Their Function Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors John C. McGrath and Craig J. Daly Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors Dianne M. Perez Part IV: Genetically Altered Mouse Models The a1-Adrenergic Receptors: Lessons From Knockout Paul C. Simpson The a2-Adrenergic Receptors: Lessons From Knockouts Christopher M. Tan and Lee E. Limbird The b-Adrenergic Receptors: Lessons From Knockouts Yang Xiang and Brian Kobilka Lessons From Overexpressed Mouse Models Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman Adrenergic Receptor Signaling Components in Gene Therapy Andrea D. Eckhart and Walter J. Koch Part V: Pharmacogenomics Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms Stephen B. Liggett Microarray Analysis of Novel Adrenergic Receptor Functions Boyd Rorabaugh, June Yun, and Dianne M. Perez Part VI: Summary and Future Endeavors Summary and Future Endeavors Dianne M. Perez Index

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