The adrenergic receptors : in the 21st century
著者
書誌事項
The adrenergic receptors : in the 21st century
(Receptors)
Humana Press, c2006
大学図書館所蔵 全7件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
目次
Part I: Historical Perspectives
Adrenergic Receptors: Historical Perspectives From the 20th Century
David B. Bylund
Part II: Structure-Function
Ligand Binding, Activation, and Agonist Trafficking
Angela M. Finch, Valerie Sarramegna, and Robert M. Graham
New Signal Transduction Paradigms
Kenneth P. Minneman
Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors
Michael T. Piascik, Mary Lolis Garcia-Cazarin, and Steven R. Post
Adrenergic Receptors in Clinical Medicine
Martin C. Michel and Paul A. Insel
Part III: Imaging Adrenergic Receptors and Their Function
Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors
John C. McGrath and Craig J. Daly
Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors
Dianne M. Perez
Part IV: Genetically Altered Mouse Models
The a1-Adrenergic Receptors: Lessons From Knockout
Paul C. Simpson
The a2-Adrenergic Receptors: Lessons From Knockouts
Christopher M. Tan and Lee E. Limbird
The b-Adrenergic Receptors: Lessons From Knockouts
Yang Xiang and Brian Kobilka
Lessons From Overexpressed Mouse Models
Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman
Adrenergic Receptor Signaling Components in Gene Therapy
Andrea D. Eckhart and Walter J. Koch
Part V: Pharmacogenomics
Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms
Stephen B. Liggett
Microarray Analysis of Novel Adrenergic Receptor Functions
Boyd Rorabaugh, June Yun, and Dianne M. Perez
Part VI: Summary and Future Endeavors
Summary and Future Endeavors
Dianne M. Perez
Index
「Nielsen BookData」 より