The adrenergic receptors : in the 21st century
Author(s)
Bibliographic Information
The adrenergic receptors : in the 21st century
(Receptors)
Humana Press, c2006
Available at 7 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
Table of Contents
Part I: Historical Perspectives
Adrenergic Receptors: Historical Perspectives From the 20th Century
David B. Bylund
Part II: Structure-Function
Ligand Binding, Activation, and Agonist Trafficking
Angela M. Finch, Valerie Sarramegna, and Robert M. Graham
New Signal Transduction Paradigms
Kenneth P. Minneman
Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors
Michael T. Piascik, Mary Lolis Garcia-Cazarin, and Steven R. Post
Adrenergic Receptors in Clinical Medicine
Martin C. Michel and Paul A. Insel
Part III: Imaging Adrenergic Receptors and Their Function
Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors
John C. McGrath and Craig J. Daly
Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors
Dianne M. Perez
Part IV: Genetically Altered Mouse Models
The a1-Adrenergic Receptors: Lessons From Knockout
Paul C. Simpson
The a2-Adrenergic Receptors: Lessons From Knockouts
Christopher M. Tan and Lee E. Limbird
The b-Adrenergic Receptors: Lessons From Knockouts
Yang Xiang and Brian Kobilka
Lessons From Overexpressed Mouse Models
Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman
Adrenergic Receptor Signaling Components in Gene Therapy
Andrea D. Eckhart and Walter J. Koch
Part V: Pharmacogenomics
Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms
Stephen B. Liggett
Microarray Analysis of Novel Adrenergic Receptor Functions
Boyd Rorabaugh, June Yun, and Dianne M. Perez
Part VI: Summary and Future Endeavors
Summary and Future Endeavors
Dianne M. Perez
Index
by "Nielsen BookData"