B cell trophic factors and B cell antagonism in autoimmune disease

著者

    • Stohl, William

書誌事項

B cell trophic factors and B cell antagonism in autoimmune disease

volume editor, William Stohl

（Current directions in autoimmunity, v. 8）

Karger, c2005

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注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.

目次

  • Foreword: Stohl, W. Determinations of B Cell Fate in Immunity and Autoimmunity: Noelle, R.J.
  • Erickson, L.D. Regulatory Roles for Cytokine-Producing B Cells in Infection and Au toimmune Disease: Lund, F.E.
  • Garvy, B.A.
  • Randall, T.D.
  • Harris, D.P. The CD19-CD21 Signal Transduction Complex of B Lymphocytes Regulate s the Balance between Health and Autoimmune Disease: Systemic Scler osis as a Model System: Tedder, T.F.
  • Poe, J.C.
  • Fujimoto, M.
  • Haas, K.M.
  • Sato, S. Marginal Zone B Cell Physiology and Disease: Lopes-Carvalho, T.
  • Ke arney, J.F. Dendritic Cells Control B Cell Growth and Differentiation: Jego, G.
  • Pascual, V.
  • Palucka, A.K.
  • Banchereau, J. The Biology of CD20 and Its Potential as a Target for mAb Therapy: Cragg, M.S.
  • Walshe, C.A.
  • Ivanov, A.O.
  • Glennie, M.J. B Lymphocyte Depletion in Rheumatoid Arthritis: Targeting of CD20: Edwards, J.C.W.
  • Leandro, M.J.
  • Cambridge, G. Treatment of SLE with Anti-CD20 Monoclonal Antibody: Looney, R.J.
  • Anolik, J.
  • Sanz, I. The Biochemistry and Biology of BAFF, APRIL and Their Receptors: Ka lled, S.L.
  • Ambrose, C.
  • Hsu, Y.-M. The BAFF/APRIL System: An Important Player in Systemic Rheumatic Di seases: Mackay, F.
  • Sierro, F.
  • Grey, S.T.
  • Gordon, T.P. Human B Lymphocyte Malignancies: Exploitation of BLyS and APRIL and Their Receptors: Jelinek, D.F.
  • Darce, J.R. BlySfulness Does Not Equal Blissfulness in Systemic Lupus Erythemat osus: A Therapeutic Role for BLyS Antagonists: Stohl, W. Author Index Subject Index

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