Anticancer agents from natural products

著者

    • Cragg, Gordon M.
    • Kingston, David G. I.
    • Newman, David J.

書誌事項

Anticancer agents from natural products

edited by Gordon M. Cragg, David G.I. Kingston, David J. Newman

Taylor & Francis, 2005

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内容説明・目次

内容説明

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screening techniques and molecular targets proliferate, natural products are once again taking a central part of modern pharmaceutical research. Anticancer Agents from Natural Products analyzes current clinically-used anticancer agents that are natural products or clearly derived from natural product leads. This multi-authored volume provides a historical, biochemical, and chemical rationale to the search for plant, marine, or microbial sources that may provide future templates for drug lead optimization and synthetic drug design. Grouped by source organism, each chapter includes the history of the drug and a discussion of its mechanism in action, medicinal chemistry, and biochemistry. The authors characterize each compound by its structure, genetics, molecular biology, synthesis, and possible derivatives. They also discuss \approaches to drug discovery and development, including the use of combinatorial biosynthetic techniques, testing methods, and ways to obtain economically viable amounts of the drug. The final chapter covers drug candidates that are in preclinical or clinical development and may be used in the future. Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products is a convenient summary of the current status of research and development of some of the most effective anticancer agents available today. It is an ideal foundation for scientists engaged in developing new and improved drugs based on natural sources.

目次

  • Introduction
  • G.M. Cragg, David G. I. Kingston, and D.J. Newman Camptothecin and its Analogs
  • N.J. Rahier, C.J. Thomas, and S.M. Hecht The Discovery and Development of the Combretastatins
  • K.G. Pinney, C. Jelinek, K. Edvardsen, D.J. Chaplin, and G.R. Pettit Homoharringtonine and Related Compounds
  • H. Itokawa, X. Wang, and K.-H. Lee Podophyllotoxins and Analogs
  • K.-H. Lee and Z. Xiao Taxol and Its Analogs
  • David G. I. Kingston The Vinca Alkaloids
  • F. Gueritte and J. Fahy The Bryostatins
  • D.J. Newman The Isolation, Characterization, and Development of a Novel Class of Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins
  • R.S. Al-Awar and C. Shih Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons
  • S.P. Gunasekera and A.E. Wright The Dolastatins: Novel Antitumor Agents from Dolabella auricularia
  • E. Flahive and J. Srirangam Ecteinascidin 743 (ET-743
  • Yondelis (TM)), Aplidine, and Kahalalide F
  • R. Henriquez, G. Faircloth, and C. Cuevas Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B
  • M.J. Yu, Y. Kishi, and B.A. Littlefield HTI-286, A Synthetic Analog of the Antimitotic Natural Product Hemiasterlin
  • R.J. Andersen and M. Roberge The Actinomycins
  • A.B. Mauger and H. Lackner Anthracyclines
  • F.M. Arcamone Ansamitocins (Maytansinoids)
  • T.-W. Yu and H.G. Floss Benzoquinone Ansamycins
  • K.M. Snader Bleomycin Group of Antitumor Agents
  • S.M. Hecht Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides
  • R. Kumar and J.W. Lown Epothilone, a Myxobacterial Metabolite with Promising Antitumor Activity
  • G. Hoefle and H. Reichenbach Enediynes
  • P.R. Hamann, J. Upeslacis, and D.B. Borders The Mitomycins
  • W.A. Remers Staurosporines and Structurally Related Indolocarbazoles as Antitumor Agents
  • M. Prudhomme Combinatorial Biosynthesis of Anticancer Natural Products
  • M.G. Thomas, K.A. Bixby, and B. Shen Developments and Future Trends in Anticancer Natural Products Drug Discovery
  • D.J. Newman and G.M. Cragg Index

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