Neonatal immunity
著者
書誌事項
Neonatal immunity
（Contemporary immunology）
Humana Press, c2005
- : alk. paper
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注記
Includes bibliographical references (p. 303-372) and index
収録内容
- Structure and function of immune system in vertebrates
- Ontogeny and development of cells mediating innate and adaptive immunity
- Phenotypic characteristics of neonatal B cells
- Molecular characteristics of neonatal B cell repertoire
- Genetically programmed temporal ordered activation of neonatal B cell clones
- Antibody response in fetus and newborn
- Effect of maternal antibodies on neonatal B cell response
- Neonatal autoimmune diseases caused by maternal pathogenic autoantibodies
- Phenotypic characteristics of neonatal T cells
- Expression of MHC molecules in neonates
- Neonatal cytokine network
- Cell-mediated immune responses in neonates
- Fetal and neonatal tolerance
- Development of efficient prophylactic vaccines and theracines for newborns and infants
内容説明・目次
内容説明
A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
目次
Structure and Function of the Immune System in Vertebrates
Ontogeny and the Development of Cells Mediating Innate and Adaptive Immunity
Phenotypic Characteristics of Neonatal B Cells
Molecular Characteristics of Neonatal B-Cell Repertoire
Genetically Programmed Temporal Ordered Activation of Neonatal B-Cell Clones
Antibody Response in Fetuses and Newborns
Effect of Maternal Antibodies on Neonatal B-Cell Response
Neonatal Autoimmune Diseases Caused by Maternal Pathogenic Autoantibodies
Phenotypic Characteristics of Neonatal T Cells
Expression of MHC Molecules in Neonates. Neonatal Cytokine Network
Cell-Mediated Immune Responses in Neonates. Fetal and Neonatal Tolerance
Development of Efficient Prophylactic Vaccines and Theracines for Newborns and Infants
References
Index.
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