The ubiquitin-proteasome system
著者
書誌事項
The ubiquitin-proteasome system
（Essays in biochemistry, v. 41）
Portland, c2005
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注記
Includes bibliographical references and index
Series editor: T.G Cotter (Ireland)
内容説明・目次
内容説明
The importance of the ubiquitin-proteasome system in cellular homoeostasis was emphasized by the award of the 2004 Nobel Prize in Chemistry to the discoverers of ubiquitin as a cofactor for intracellular non-lysosomal proteolysis. There is a voluminous literature showing that protein ubiquitylation and the degradation of ubiquitylated proteins by the 26 S proteasome controls almost every regulatory process in the cell. The contributors to this volume of "Essays in Biochemistry" focus on many different aspects of the role of the ubiquitin system in intracellular proteolysis, not only in cellular homoeostasis, but also in relation to disease. Ubiquitylation compliments and rivals protein phosphorylation/dephosphorylation in the regulation of cellular activities. Understanding the ubiquitin-proteasome system and related mechanisms will provide new therapeutic avenues in a variety of unrelated human diseases.
目次
Orchestra for assembly and fate of polyubiquitin chains - Thorsten Hoppe et al. E3 ubiquitin ligases - Helen Ardley and Philip Robinson Proteasomes - Burkhardt Dahlmannn Ubiquitin-binding proteins: similar, but different - Rasmus Hartmann-Petersen et al. Ubiquitin and control of transcription - Zafar Nawaz et al. Ubiquitin and endocytic protein sorting - Sylvie Urbe The ubiquitin-proteasome system in ER quality control - Yihong Ye Fluorescent reporters for the ubiquitin-proteasome system - Nico Dantuma Transgenic manipulation of the ubiquitin-proteasome system - Douglas Gray Targeting of host-cell ubiquitin pathways by viruses - Julia Shackelford and Joseph Pagano The ubiquitin-proteasome system and neurodegenerative disorders - Robert Layfield, James Lowe and Lynn Bedford The UPS and skeletal muscle wasting - Didier Attaix et al. The ubiquitin-proteasome system and cancer - John Mayer et al. Proteasome inhibitors as therapeutics - Constantine Mitsiades et al.
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