The carcinogenic effects of polycyclic aromatic hydrocarbons

著者

    • Luch, Andreas

書誌事項

The carcinogenic effects of polycyclic aromatic hydrocarbons

editor, Andreas Luch

Imperial College Press, 2004

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.

目次

PAH-Induced Carcinogenesis -- An Introduction (A Luch) - Metabolic Activation and Detoxification of PAHs (A Luch & W M Baird) - Biomonitoring of PAHs -- Human Exposure (A Seidel) - Macromolecular Adducts as Biomarkers of Human Exposure (D H Phillips) - DNA Damage and Mutagenesis Induced by PAHs (A Besaratinia & G P Pfeifer) - Mechanisms of Repair of PAH-Induced DNA Damage (H Naegeli & N E Geacintov) - Aberrant Gene Expression and Cell Signalling/Epigenetic Effects Induced by PAHs (P Steinberg) - Assays for the Detection of Genotoxic Activity of PAHs (H Glatt) - Tumorigenicity of PAHs -- On the Possible Contribution of PAHs and Their Nitroderivatives to the Development of Human Breast Cancer (S Amin & K El-Bayoumy) - Genetic Susceptibility to PAH-Induced Carcinogenesis (A Hirvonen) - Summary and Prospects (A Luch)

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