Molecular mimicry : infection-inducing autoimmune disease
著者
書誌事項
Molecular mimicry : infection-inducing autoimmune disease
（Current topics in microbiology and immunology, v. 296）
Springer, c2005
大学図書館所蔵 全11件
内容説明・目次
内容説明
The purpose of this review is to examine the potential role of molecular mimicry in the pathogenesis of human T-lymphotropic virus type 1 ((HTLV- 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)). Comp- hensive reviews on the pathogenic mechanisms of HTLV-1-associated human diseases are available throughout the medical literature (Bangham 2000,, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Approximately 25 years ago the ?rst human retrovirus, HTLV-1, was isolated (Poeisz et al. 1980). Subsequently, infection with HTLV-1 was shown to cause adult T-cell leukemia (ATL) and HAM/TSP (Gessain et al. 1985; McFarlin and Blattner 1991; Osame et al. 1986; Poeisz et al. 1980; Yoshida et al. 1987). HTLV-1 may infect up to 30% of people in endemic areas and 10-20 million people worldwide (Barmak et al. 2003; Edlich et al. 2000). However, only 1%-5% develop either ATL or HAM/TSP, the remainder being clinically asymptomatic carriers of HTLV-1 (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002).
Why infection with HTLV-1 causes ATL or HAM/TSP in some people while the vast majority of individuals are asymptomatic is largely - known. Some possible factors that may differentiate the asymptomatic from the diseased state include viral strain, human histocompatibility leukocyte antigen (HLA), viral load, and the immune response (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Nagai et al. 1998; Niewiesk et al. 1994; Osame 2002).
目次
Molecular Mimicry, Microbial Infection and Autoimmune Disease: Evolution of the Concept.- A Virus-Induced Molecular Mimicry Model of Multiple Sclerosis.- Suppression of Autoimmunity via Microbial Mimics of Altered Peptide Ligands.- Molecular and Cellular Mechanisms, Pathogenesis and Treatment of Insulin-Dependent Diabetes Obtained Through Study of a Transgenic Model of Molecular Mimicry.- Trypanosoma cruzi-Induced Molecular Mimicry and Chagas' Disease.- HTLV-1-Induced Molecular Mimicry in Neurologic Disease.- Molecular Mimicry: Anti-DNA Antibodies Bind Microbial and Non-Nucleic Acid Self Antigens.- The Structural Interactions Between T-Cell Receptors and MHC/Peptide Complexes Place Physical Limits on Self-Nonself Discrimination.- Subject Index
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