Medicinal chemistry : a molecular and biochemical approach
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Bibliographic Information
Medicinal chemistry : a molecular and biochemical approach
Oxford University Press, 2005
3rd ed
- : cloth
- : pbk
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Note
Includes bibliographical references and index
Description and Table of Contents
- Volume
-
: cloth ISBN 9780195104554
Description
Fully updated and rewritten by a basic scientist, who is also a practising physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, "Medicinal Chemistry" examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then, it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined.
Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modelling techniques, high throughput screening, neurpharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
Table of Contents
- PART A: GENERAL MOLECULAR PRINCIPLES OF DRUG DESIGN
- 1. Basic Principles of Drug Design I: Drug Molecules: Structure and Properties
- 2. Basic Principles of Drug Design II: Receptors: Structures and Properties
- 3. Basic Principles of Drug Design III: Designing Drug Molecules to Fit Receptors
- PART B: BIOCHEMICAL CONSIDERATIONS IN DRUG DESIGN
- 4. Messenger Targets for Drug Action I: Neurotransmitters and Their Receptors
- 5. Messenger Targets for Drug Action II: Hormones and Their Receptors
- 6. Messenger Targets for Drug Action III: Immunomodulators and Their Receptors
- 7. Nonmessenger Targets for Drug Action I: Endogenous Cellular Structures
- 8. Nonmessenger Targets for Drug Action II: Endogenous Macromolecules
- 9. Nonmessenger Targets for Drug Action III: Exogenous "Nonself" Pathogens
- Appendix A: Drugs arranged by pharmacologic activity
- Volume
-
: pbk ISBN 9780195104561
Description
Fully updated and rewritten by a basic scientist who is also a practising physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better
understanding of drug design, will find this book an invaluable resource.
Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles
(mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are exained. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.
There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neurpharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and
ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's
appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
Table of Contents
- PART I: GENERAL MOLECULAR PRINCIPLES OF DRUG DESIGN
- PART II: BIOCHEMICAL CONSIDERATIONS IN DRUG DESIGN: FROM DRUGGABLE TARGETS TO DISEASES
by "Nielsen BookData"