Telomeres
著者
書誌事項
Telomeres
（Cold Spring Harbor monograph series, 45）
Cold Spring Harbor Laboratory Press, 2006
2nd ed
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
An up-to-date survey of the current exciting state of telomere biology. Telomeres - specialized structures found at the ends of chromosomes - are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.
目次
1. A History of Telomere Biology 2. The Telomerase Ribonucleoprotein Particle 3. Telomerase Biochemistry and Biogenesis 4. Telomerase and Human Cancer 5. Modeling Cancer and Aging in the Telomerase-deficient Mouse 6. Telomerase Deficiency and Human Disease 7. Telomerase-independent Maintenance of Mammalian Telomeres 8. Telomerase-independent Telomere Maintenance in Yeast 9. Meiotic Telomeres 10. Telomere Position Effect: Silencing Near the End 11. The Structural Biology of Telomeres 12. Budding Yeast Telomeres 13. Mammalian Telomeres 14. Drosophila Telomeres 15. Ciliate Telomeres 16. Fission Yeast Telomeres 17. Plant Telomeres Appendix: A Personal Account of The Discovery of Telomerase Index
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