Natural products : drug discovery and therapeutic medicine
著者
書誌事項
Natural products : drug discovery and therapeutic medicine
Humana Press, c2005
大学図書館所蔵 全9件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
HTTP:URL=http://www.loc.gov/catdir/toc/ecip053/2004026635.html Information=Table of contents
Includes bibliographies and index
内容説明・目次
内容説明
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
目次
Part I. Fundamental Issues Related to Natural Product-Based Drug Delivery
Natural Products and Drug Discovery
Arnold L. Demain and Lixin Zhang
Part II. Strategies
Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products
Lixin Zhang
Automated Analyses of HPLC Profiles of Microbial Extracts: A New Tool for Drug Discovery Screening
Jose R. Tormo and Juan B. Garcia
Manipulating Microbial Metabolites for Drug Discovery and Production
C. Richard Hutchinson
Improving Drug Discovery From Microorganisms
Chris M. Farnet and Emmanuel Zazopoulos
Developments in Strain Improvement Technology: Evolutionary Engineering of Industrial Microorganisms Through Gene, Pathway, and Genome Shuffling
Stephen B. del Cardayre
Part III. Specific Groups of Drugs
The Discovery of Anticancer Drugs From Natural Sources
David J. Newman and Gordon M. Cragg
Case Studies in Natural-Product Optimization: Novel Antitumor Agents Derived From Taxus brevifolia and Catharanthus roseus
Jian Hong and Shu-Hui Chen
Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
Guangyi Wang, Weiping Tang, and Robert R. Bidigare
Challenges and Opportunities in the Chinese Herbal Drug Industry
Wei Jia and Lixin Zhang
Arsenic Trioxide and Leukemia: From Bedside to Bench
Guo-Qiang Chen, Qiong Wang, Hua Yan, and Zhu Chen
Part IV. Microbial Diversity
New Methods to Access Microbial Diversity for Small Molecule Discovery
Karsten Zengler, Ashish Paradkar, and Martin Keller
Accessing the Genomes of Uncultivated Microbes for Novel Natural Products
Asuncion Martinez, Joern Hopke, Ian A. MacNeil, and Marcia S. Osburne
Part V. Specific Sources
New Natural-Product Diversity From Marine Actinomycetes
Paul R. Jensen and WilliamFenical
Novel Natural Products From Rainforest Endophytes
Gary Strobel, Bryn Daisy, and Uvidelio Castillo
Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador
Alexandra Guevara-Aguirre and Ximena Chiriboga
Index
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