Natural products : drug discovery and therapeutic medicine
Author(s)
Bibliographic Information
Natural products : drug discovery and therapeutic medicine
Humana Press, c2005
Available at 9 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
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  Sweden
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  United States of America
Note
HTTP:URL=http://www.loc.gov/catdir/toc/ecip053/2004026635.html Information=Table of contents
Includes bibliographies and index
Description and Table of Contents
Description
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Table of Contents
Part I. Fundamental Issues Related to Natural Product-Based Drug Delivery
Natural Products and Drug Discovery
Arnold L. Demain and Lixin Zhang
Part II. Strategies
Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products
Lixin Zhang
Automated Analyses of HPLC Profiles of Microbial Extracts: A New Tool for Drug Discovery Screening
Jose R. Tormo and Juan B. Garcia
Manipulating Microbial Metabolites for Drug Discovery and Production
C. Richard Hutchinson
Improving Drug Discovery From Microorganisms
Chris M. Farnet and Emmanuel Zazopoulos
Developments in Strain Improvement Technology: Evolutionary Engineering of Industrial Microorganisms Through Gene, Pathway, and Genome Shuffling
Stephen B. del Cardayre
Part III. Specific Groups of Drugs
The Discovery of Anticancer Drugs From Natural Sources
David J. Newman and Gordon M. Cragg
Case Studies in Natural-Product Optimization: Novel Antitumor Agents Derived From Taxus brevifolia and Catharanthus roseus
Jian Hong and Shu-Hui Chen
Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
Guangyi Wang, Weiping Tang, and Robert R. Bidigare
Challenges and Opportunities in the Chinese Herbal Drug Industry
Wei Jia and Lixin Zhang
Arsenic Trioxide and Leukemia: From Bedside to Bench
Guo-Qiang Chen, Qiong Wang, Hua Yan, and Zhu Chen
Part IV. Microbial Diversity
New Methods to Access Microbial Diversity for Small Molecule Discovery
Karsten Zengler, Ashish Paradkar, and Martin Keller
Accessing the Genomes of Uncultivated Microbes for Novel Natural Products
Asuncion Martinez, Joern Hopke, Ian A. MacNeil, and Marcia S. Osburne
Part V. Specific Sources
New Natural-Product Diversity From Marine Actinomycetes
Paul R. Jensen and WilliamFenical
Novel Natural Products From Rainforest Endophytes
Gary Strobel, Bryn Daisy, and Uvidelio Castillo
Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador
Alexandra Guevara-Aguirre and Ximena Chiriboga
Index
by "Nielsen BookData"