Nitric oxide donors : for pharmaceutical and biological applications
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書誌事項
Nitric oxide donors : for pharmaceutical and biological applications
Wiley-VCH, c2005
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
目次
Part 1: Chemistry of NO Donors.1 NO and NO Donors (Tingwei Bill Cai, Peng George Wang, and Alvin A. Holder).2 Organic Nitrates and Nitrites (Roger Harrison).3 N-Nitroso Compounds (Arindam Talukdar, Peng George Wang).4 The Role of S-Nitrosothiols in the Biological Milieu (Bulent Mutus).5 Metal-NO complexes: Structures, Syntheses, Properties and NO-releasing Mechanisms (Tara P. Dasgupta, Danielle V. Aquart).6 The NO-releasing Heterocycles (Alberto Gasco, Karl Schoenafinger).7 C-Nitroso Compounds, Oximes, N-Hydroxyguanidines and N-Hydroxyureas (S. Bruce King).Part 2: NO Donors' Applications in Biological Research.8 Vasodilators for Biological Research (Anthony Robert Butler, Russell James Pearson).9 NO Donors as Antiplatelet Agents (Anna Kobsar, Martin Eigenthaler).10 Control of NO Production (Noriko Fujiwara, Keiichiro Suzuki, Naoyuki Taniguchi).Part 3: Clinical Applications of NO Donors.11 Nitric Oxide Donors in Cardiovascular Disease (Martin Feelisch, Joseph Loscalzo).12 Nitric Oxide Donors as Anti-platelet Agents for Thromboembolic Disorders: Clinical Status and Therapeutic Prognosis (David R. Janero, David S. Garvey).13 NO and Gene Regulation (Jie Zhou, Bernhard Brune).14 Nitric Oxide and Central Nervous System Diseases (Elizabeth Mazzio, Karam F. A. Soliman).Index.
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