Medicinal inorganic chemistry
著者
書誌事項
Medicinal inorganic chemistry
(ACS symposium series, 903)
American Chemical Society, c2005
大学図書館所蔵 全5件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
"Sponsored by the ACS divisions of Inorganic Chemistry, Inc. and Medicinal Chemistry."
Includes bibliographies and indexes
内容説明・目次
内容説明
This book, a compilation by experts in the field, is designed to provide an introduction to the area of medicinal inorganic chemistry and to summarize current, state-of-the-art developments in the field. Medicinal inorganic chemistry represents a key thrust area in medicine and biological inorganic chemistry. It is one of great current excitement and achievement. The field of metals in medicine represents an approximate $3 billion dollar a year industry, with
successes in the area of Tc- and Gd-based imaging agents and Pt-based cancer therapeutics being major contributors to this bottom line. It has become increasingly apparent, however, that metal-based pharmaceuticals can play a prominent role in areas outside of imaging and oncology, including in those
associated with the diagnosis and treatment of metabolism- and genetic disorders, cardiovascular disease, gene therapy, inflammation, reperfusion injury, stroke, diabetes, ALS, malaria, and neurological disease to name but a few. A objective of this book, therefore, is to highlight these opportunities for future advances and to foster further interactions between those working in the metal-based drug development, including imaging agents, and those engaged in the more classic pharmaceutical
industries.
目次
1.: Stephen J. Lippard: Metal Ion Chemistry for Sustaining Life
2.: John W. Kozarich: Medicinal Inorganic Chemistry: Promises and Challenges
3.: Peter C. Preusch: Metals in Medicine: Biomedical Significance and Inorganic Chemistry
4.: Christen M. Giandomenico and Ernest Wong: Discovery and Development of Third-Generation Platinum Antitumor Agents with Oral Activity
5.: John F. Schenck: Brain Iron as an Endrogenous Contrast Agent in High Field MRI
6.: Nicholas Farrell: Platinum Anticancer Drugs: From Laboratory to Clinic
7.: Jan Reedik: Mechanistic Studies of Pt and Ru Compounds with Antitumor Properties
8.: Darren J. Magda, Nikolay Gerasimchuk, Zhong Wang, Jonathan L. Sessler, and Richard A. Miller: Mechanistic Studies of Motexafin Gadolinium (Xcyrin): A Redox Active Agent That Reacts with Electron-Rich Biological Substrates
9.: Pier Lucio Anelli, Marino Brocchetta, Vito Lorusso, Giuseppe Manfredi, Alberto Morisetti, Pierfrancesco Morosini, Marcella Murru, Daniela Palano, and Massimo Visigalli: Bile Acids at Work: Development of a New Intravascular MRI Contrast Agent
10.: A. Dean Sherry, Shanrong Zhang, and Mark Woods: Water Exchange is the Key Parameter in the Design of Next-Generation MRI Agents
11.: Peter Caravan: Targeted Molecular Imaging with MRI
12.: Johannes Platzek and Heribert Schmitt-Willich: Synthesis and Development of Gadomer: A Dendritic MRI Contrast Agent
13.: Jack T. Rogers: Amyloid Precursor Protein and Ferritin Translation: Implications for Metals and Alzheimer's Disease Therapeutics
14.: George J. Brewer: Anticopper Therapy with Tetrathiomolybdate for Wilson's Disease, Cancer, and Diseases of Inflammation and Fibrosis
15.: Clare Kenny Carney, Lisa Pasierb, and David Wright: Heme Detoxification in Malaria: A Target Rich Environment
16.: Anne Robert, Francoise Benoit-Vical, and Bernard Meunier: Heme as a Trigger and Target of the Antimalarial Peroxide Artemisinin
17.: John P. Crow: Administration of Mn Polyyrin and Mn Texaphyrin at Symptom Onset Extends Survival of ALS Mice
18.: Susan R. Doctorow, Michael Baudry, Karl Huffman, Bernard Malfroy, and Simon Melov: Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging
19.: P. John Hart and Joan Selverstone Valentine: Metal Deficient Copper-Zinc Superixide Dismutase and Familial Amyotrophic Lateral Sclerosis: Pathogenic SOD1 Oligomerization through Non-Native Protein-Protein Interactions
20.: Raymond J. Bergeron, Jan Wiegand, James S. McManis, William R. Weimar, Jeong-Hyun Park, Eileen Eiler-McManis, Jennifer Bergeron, and Gary M. Brittenham: Impact of the Lipophilicity of Desferrithiocin Anaglogues on Iron Clearance
21.: Katherine H. Thompson, Barry D. Liboiron, Graeme R. Hanson, and Chris Orvig: In Vivo Coordination Chemistry and Biocalization of Bis(ligand)oxovanadium(IV) Complexes for Diabetes Treatment
22.: Patrick J. Farmer, Daniel Brayton, Christina Moore, Donny Williams, Babbak Shahandeh, Dazhi Cen, and Frank Meyskens, Jr.: Targeting Melanoma via Metal-Based Stress
23.: Wiley J. Youngs, Claire A. Tesslier, Jared C. Garrison, Carol A. Quezada, Abdulkareem Melaiye, Semih Durmus, Matthew J. Panzer, and Aysegul Kascatan-Nebioglu: Medicinal Applications of Metal Complexes of N-Heterocyclic Carbenes
「Nielsen BookData」 より