Medicinal inorganic chemistry
Author(s)
Bibliographic Information
Medicinal inorganic chemistry
（ACS symposium series, 903）
American Chemical Society, c2005
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"Sponsored by the ACS divisions of Inorganic Chemistry, Inc. and Medicinal Chemistry."
Includes bibliographies and indexes
Description and Table of Contents
Description
This book, a compilation by experts in the field, is designed to provide an introduction to the area of medicinal inorganic chemistry and to summarize current, state-of-the-art developments in the field. Medicinal inorganic chemistry represents a key thrust area in medicine and biological inorganic chemistry. It is one of great current excitement and achievement. The field of metals in medicine represents an approximate $3 billion dollar a year industry, with
successes in the area of Tc- and Gd-based imaging agents and Pt-based cancer therapeutics being major contributors to this bottom line. It has become increasingly apparent, however, that metal-based pharmaceuticals can play a prominent role in areas outside of imaging and oncology, including in those
associated with the diagnosis and treatment of metabolism- and genetic disorders, cardiovascular disease, gene therapy, inflammation, reperfusion injury, stroke, diabetes, ALS, malaria, and neurological disease to name but a few. A objective of this book, therefore, is to highlight these opportunities for future advances and to foster further interactions between those working in the metal-based drug development, including imaging agents, and those engaged in the more classic pharmaceutical
industries.
Table of Contents
1.: Stephen J. Lippard: Metal Ion Chemistry for Sustaining Life
2.: John W. Kozarich: Medicinal Inorganic Chemistry: Promises and Challenges
3.: Peter C. Preusch: Metals in Medicine: Biomedical Significance and Inorganic Chemistry
4.: Christen M. Giandomenico and Ernest Wong: Discovery and Development of Third-Generation Platinum Antitumor Agents with Oral Activity
5.: John F. Schenck: Brain Iron as an Endrogenous Contrast Agent in High Field MRI
6.: Nicholas Farrell: Platinum Anticancer Drugs: From Laboratory to Clinic
7.: Jan Reedik: Mechanistic Studies of Pt and Ru Compounds with Antitumor Properties
8.: Darren J. Magda, Nikolay Gerasimchuk, Zhong Wang, Jonathan L. Sessler, and Richard A. Miller: Mechanistic Studies of Motexafin Gadolinium (Xcyrin): A Redox Active Agent That Reacts with Electron-Rich Biological Substrates
9.: Pier Lucio Anelli, Marino Brocchetta, Vito Lorusso, Giuseppe Manfredi, Alberto Morisetti, Pierfrancesco Morosini, Marcella Murru, Daniela Palano, and Massimo Visigalli: Bile Acids at Work: Development of a New Intravascular MRI Contrast Agent
10.: A. Dean Sherry, Shanrong Zhang, and Mark Woods: Water Exchange is the Key Parameter in the Design of Next-Generation MRI Agents
11.: Peter Caravan: Targeted Molecular Imaging with MRI
12.: Johannes Platzek and Heribert Schmitt-Willich: Synthesis and Development of Gadomer: A Dendritic MRI Contrast Agent
13.: Jack T. Rogers: Amyloid Precursor Protein and Ferritin Translation: Implications for Metals and Alzheimer's Disease Therapeutics
14.: George J. Brewer: Anticopper Therapy with Tetrathiomolybdate for Wilson's Disease, Cancer, and Diseases of Inflammation and Fibrosis
15.: Clare Kenny Carney, Lisa Pasierb, and David Wright: Heme Detoxification in Malaria: A Target Rich Environment
16.: Anne Robert, Francoise Benoit-Vical, and Bernard Meunier: Heme as a Trigger and Target of the Antimalarial Peroxide Artemisinin
17.: John P. Crow: Administration of Mn Polyyrin and Mn Texaphyrin at Symptom Onset Extends Survival of ALS Mice
18.: Susan R. Doctorow, Michael Baudry, Karl Huffman, Bernard Malfroy, and Simon Melov: Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging
19.: P. John Hart and Joan Selverstone Valentine: Metal Deficient Copper-Zinc Superixide Dismutase and Familial Amyotrophic Lateral Sclerosis: Pathogenic SOD1 Oligomerization through Non-Native Protein-Protein Interactions
20.: Raymond J. Bergeron, Jan Wiegand, James S. McManis, William R. Weimar, Jeong-Hyun Park, Eileen Eiler-McManis, Jennifer Bergeron, and Gary M. Brittenham: Impact of the Lipophilicity of Desferrithiocin Anaglogues on Iron Clearance
21.: Katherine H. Thompson, Barry D. Liboiron, Graeme R. Hanson, and Chris Orvig: In Vivo Coordination Chemistry and Biocalization of Bis(ligand)oxovanadium(IV) Complexes for Diabetes Treatment
22.: Patrick J. Farmer, Daniel Brayton, Christina Moore, Donny Williams, Babbak Shahandeh, Dazhi Cen, and Frank Meyskens, Jr.: Targeting Melanoma via Metal-Based Stress
23.: Wiley J. Youngs, Claire A. Tesslier, Jared C. Garrison, Carol A. Quezada, Abdulkareem Melaiye, Semih Durmus, Matthew J. Panzer, and Aysegul Kascatan-Nebioglu: Medicinal Applications of Metal Complexes of N-Heterocyclic Carbenes
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