Thrombolytic therapy for acute stroke

著者

書誌事項

Thrombolytic therapy for acute stroke

edited by Patrick D. Lyden

（Current clinical neurology）

Humana Press, c2005

2nd ed

大学図書館所蔵 件 / 全4件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

内容説明

It often takes time for a new therapeutic modality to mature into an accepted treatment option. After initial approval, new drugs, devices, and procedures all go through this process until they become "vetted" by the scientific community as well as the medical community at large. Thrombolysis for treatment of stroke is no exception. Thrombolytic Therapy for Acute Stroke, Second Edition comes four years after the first edition and provides a very comprehensive, updated perspective on the use of intravenous rt-TPA in acute stroke. The authors provide longer term follow-up on the pivotal clinical trials that led to Food and Drug Administration approval, data concerning phase 4 trials in larger numbers of patients, and, most importantly, the community experience that has accumulated since its release. They add to this the latest promising information concerning intra-arterial thrombolysis, which is still under investigation and more speculative sections concerning possible new avenues of clinical research such as combining intravenous thr- bolysis with neuroprotective therapies or intra-arterial thrombolysis. A wealth of factual information is supplemented by chapters containing sage opinion from Drs. Lyden and Caplan concerning the logistical, economic, and procedural issues that have been generated since the advent of this technology. Importantly, diagnosis does not take a back seat to therapeutics as illustrated by sections devoted to eva- ation of the stroke patient, very useful illustrative cases and clinical comments, and chapters on the latest in imaging as applied to this field.

目次

Part I: Background and Basic Investigations Mechanisms of Thrombolysis Gregory J. del Zoppo and Naohisa Hosomi Pathology of Cervico-Cranial Artery Occlusion Louis R. Caplan The Ischemic Penumbra and Neuronal Salvage Patrick D. Lyden Part II: Scientific Rationale and Clinical Trials Pre-Clinical Testing of Thrombolytic Therapy for Acute Ischemic Stroke Steven R. Levine Combination of Thrombolytic Therapy With Neuroprotectants James C. Grotta and Lise A. Labiche Pilot and Preliminary Studies of Thrombolytic Therapy for Stroke Steven R. Levine, E. Clarke Haley, and Patrick D. Lyden Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large Randomized Clinical Trials Matthew L. Flaherty, Edward C. Jauch, Rashmi U. Kothari, and Joseph P. Broderick Further Analysis of NINDS Study: Long-Term Outcome, Subgroups, and Cost Effectiveness Susan C. Fagan, Thomas D. Kwiatkowski, and Patrick D. Lyden Community Experience With Intravenous Thrombolysis for Acute Stroke Lama Al-Khoury and Christy M. Jackson Intra-Arterial Thrombolysis in Acute Ischemic Stroke Anthony J. Furlan, Randall Higashida, Irene Katzan, Alex Abou-Chebl, and Andrew N. Russman Combinations of Intravenous and Intra-Arterial Thrombolysis Matthew L. Flaherty and Joseph Broderick Part III: Using Thrombolysis for Acute Stroke Thrombolysis in Vertebrobasilar Occulsive Disease Louis R. Caplan Thrombolytic Therapy in Stroke Patients Patrick D. Lyden Stroke Thrombolysis: The Present Guidelines and Policies for Clinical Use Should Be Changed Louis R. Caplan How to Run a Stroke Code Askiel Bruno The Impact of Computed Tomography on Acute Stroke Treatment Rudiger von Kummer Using Magnetic Resonance Imaging to Select andManage Patients for Treatment Peter D. Schellinger, Chelsea S. Kidwell, and Steven Warach The rt-PA for Acute Stroke Protocol John Marler and Patrick D. Lyden Part IV: Illustrative Cases Illustrative Cases Index

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