Alzheimer's disease: cellular and molecular aspects of amyloid β
著者
書誌事項
Alzheimer's disease: cellular and molecular aspects of amyloid β
（Subcellular biochemistry, 38）
Springer, c2005
- タイトル別名
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Alzheimer's disease: cellular and molecular aspects of amyloid beta
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
目次
1. The Contribution of Microscopy to the Study of Amyloid Plaques and to Amyloid-ss Fibrillogenesis J. ROBIN HARRIS 2. Transgenic Mouse Models for APP Processing and Alzheimer's Disease: Early and Late Defects Tom Van Dooren, Ilse Dewachter, Peter Borghgraef and Fred Van Leuven 3. Oxidative stress in Alzheimer's Disease: Implications for Prevention and Therapy CHRISTIAN BEHL 4. ss-Secretase, APP and Ass in Alzheimer's Disease ROBERT VASSAR 5. The Non-Amyloidogenic Pathway: Structure and Function of a-Secretases Elzbieta Kojro and Falk Fahrenholz 6. Amyloid ss Degradation: A Challenging Task for Brain Peptidases Laura Morelli, Ayelen Bulloj, Maria Celeste Leal and Eduardo M. Castano 7. The Protective Role of Vitamin E in Vascular Amyloid ss-Mediated Damage Francisco Jose Munoz, Montserrat Sole and Mireia Coma 8. Amyloid Accumulation and Pathogensis of Alzheimer's Disease: Significance of Monomeric, Oligomeric and Fibrillar Ass Charles C. Glabe 9. Cholesterol and Amyloid ss Fibrillogenesis Katsuhiko Yanagisawa 10. Alzheimer's b-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding Hideyo Inouye and Daniel A. Kirschner 11. The Aluminium-Amyloid Cascade Hypothesis and Alzheimer's Disease CHRISTOPHER EXLEY 12. Amyloid-ss Metal Interaction and Metal Chelation Math P. Cuajungco, Christopher, J. Frederickson and Ashley I. Bush 13. The Interaction of Amyloid-ss with ApoE Donald B. Carter 14. Clusterin and Alzheimer's Disease Miguel Calero, Agueda Rostagno, Blas Frangione and Jorge Ghiso 15. Acetylcholinesterase Interaction with Alzheimer Amyloid ss Nibaldo C. Inestrosa, Juan Paulo Sagaland Marcela Colombres 16. Membrane Disordering Effects of ss-Amyloid Peptides Gunter P. Eckert, W.G. Wood and Werner E. Muller 17. The Role of Alzheimer Ass Peptides in Ion Transport Across Cell Membranes Vernon M. Ingram 18. Amyloid Inhibitors and ss-Sheet Breakers Claudio Soto and Lisbell Estrada 19. Cholesterol and Alzheimer's Disease: Statins, Cholesterol Depletion in APP Processing and Ass Generation Tobias Hartmann 20. Phosphorylated Amyloid-ss: The Toxic Intermediate in Alzheimer's Disease Neurodegeneration NATHANIEL G. N. MILTON Index
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