Drug-membrane interactions : analysis, drug distribution, modeling
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Bibliographic Information
Drug-membrane interactions : analysis, drug distribution, modeling
（Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], v. 15）
Wiley-VCH, c2002
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Includes bibliographies and index
Description and Table of Contents
Description
Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. It is a recommended reading for everyone involved in pharmaceutical research.
Table of Contents
Preface. Foreword. INTRODUCTION Function, Composition, and Organization of Membranes OCTANOL--WATER PARTITION VERSUS PARTITIONING INTO MEMBRANES ANALYTICAL TOOLS FOR THE ANALYSIS AND QUANTIFICATION OF DRUG--MEMBRANE INTERACTIONS High--performance Liquid Chromatography (HPLC) Displacement of 45Ca from Phospholipid Head Groups Differential Scanning Calorimetry (DSC) Fluorescence Techniques Fourier Transform Infrared Spectroscopy (FT--IR) Electron Spin Resoncance (ESR) Small Angle Neutron and X--ray Diffraction Nuclear Magnetic Resonance (NMR) Circular Dichroism (CD) UV Spectroscopy DRUG--MEMBRANE INTERACTIONS AND PHARMACOKINETICS OF DRUGS Drug Transport Drug Distribution Uptake into and Distribution within Bacterial Cells Drug Accumulation, Toxicity, and Selectivity DRUG--MEMBRANE INTERACTIONS AND PHARMACODYNAMICS Drug Efficacy Drug Resistance COMPUTER SIMULATION OF PHOSPHOLIPIDS AND DRUG--PHOSPHOLIPID INTERACTIONS Modeling Strategies for Studying Phospholipids and Drug--Phospholipid Interactions Computer Simulations with Phospholipids Concluding Remarks INDEX
by "Nielsen BookData"