Chimeric toxins : mechanisms of action and therapeutic applications
Author(s)
Bibliographic Information
Chimeric toxins : mechanisms of action and therapeutic applications
(Cellular and molecular mechanisms of toxin action, v. 4)
Taylor & Francis, 2002
Available at 2 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalization and translocation across the cell membrane, and interaction with intracellular components. Because of their potency in killing eukaryotic cells, they have been used in the development of novel agents for targeted immunotherapy, and have been termed 'chimeric toxins'.
The elucidation of the mechanism of action of protein toxins remains a complex problem, but understanding these mechanisms will open new avenues for the design of novel therapies for the treatment of toxin-related diseases. In Chimeric Toxins: Mechanisms of Action and Therapeutic Applications, the authors review the structure, function and mechanisms of toxic action and investigate their therapeutic applications in medicine, including approaches used to design, express and purify these molecules as well as discussing their characteristics and in vivo efficacy.
Table of Contents
Bacterial and Plant Toxins - General Mode of Action. Diphtheria Toxin-Structure, Function and its Therapeutic Use. Ricin A-Structure, Function and its Clinical Applications. Pathways of Delivering Toxins into the Cytosol of Target Cells. Engineering Immunotoxins for Improving their Therapeutic Activity. Ligand-receptor Interactions Studied with Chimeric Proteins. Chimeric Proteins: a Novel Approach for Eliminating Specific Cell Populations for Targeted Human Therapy. Chimeric Neurotoxins - a Molecular Neurosurgery Approach. Targeted Immunotherapy of Autoimmune Diseases by Chimeric Toxins. Immunotoxins for Targeted Cancer Therapy. Molecular Targeting of Brain Tumors with Cytotoxins. Toxins in the Development of Vaccines.
by "Nielsen BookData"