In vitro neurotoxicology : principles and challenges

著者

書誌事項

In vitro neurotoxicology : principles and challenges

edited by Evelyn Tiffany-Castiglioni ; foreword by Mannfred A. Hollinger

（Methods in pharmacology and toxicology / Mannfred A. Hollinger, series editor）

Humana Press, c2004

  • : e-book

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注記

"Annotated reading list": p. 315-323

Includes bibliographies and index

内容説明・目次

内容説明

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.

目次

In Vitro Neurotoxicology: Introduction to Concepts Evelyn Tiffany-Castiglioni Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment Marion Ehrich and David C. Dorman Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics William H. Hanneman, Melvin E. Andersen, Marie E. Legare, Christine T. French, Tami S. McMullin, Carolyn Broccardo, and Ruth E. Billings In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis Gerald J. Audesirk and Ronald B. Tjalkens Role of Apoptosis in Neurotoxicology Lori D. White, Sid Hunter, Michael W. Miller, Marion Ehrich, and Stanley Barone, Jr. Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia Michael Aschner and Ursula Sonnewald Cell-Type-Specific Responses of the Nervous System to Lead Evelyn Tiffany-Castiglioni and Yongchang Qian Effects of Toxicants on Neural Differentiation Stanley Barone, Jr., Prasada R. S. Kodavanti, and William R. Mundy Impairment of Synaptic Function by Exposure to Lead Stephen M. Lasley and Mary E. Gilbert Aggregating Brain Cell Cultures for Neurotoxicological Studies Marie-Gabrielle Zurich, Florianne Monnet-Tschudi, Lucio G. Costa, Benoit Schilter, and Paul Honegger Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors W. Les Dees, Jill K. Hiney, Robert K. Dearth, and Vinod K. Srivastava Establishing In Vitro Models to Study Endogenous Neurotoxicants Heather D. Durham Appendix: Annotated Reading List Evelyn Tiffany-Castiglioni, Lucio G. Costa, Marion Ehrich, William R. Mundy, Gerald J. Audesirk, Michael Aschner, Prasada R. S. Kodavanti, and Stephen M. Lasley Index

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