Neuroglycobiology
著者
書誌事項
Neuroglycobiology
(The molecular and cellular neurobiology series)
Oxford University Press, 2005
大学図書館所蔵 全6件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Carbohydrates play a major role in the function and structure of the brain. In the past decade, tremendous progress has been made in understanding the structure, biosynthesis, and function of glycoconjugates found in the nervous system. The field of neuroglycobiology is now entering an exciting new phase with the use of molecular tools allowing us to manipulate the amount, as well as the temporal and spatially regulated expression, of those glycoconjugates. In recent years, we have gained important new knowledge on glycoproteins (polysialic acid, HNK-1 glycan), proteoglycans, and glycolipids. 'Neuroglycobiology' presents an integrative account of the latest developments in this field. This new volume in the Molecular and Cellular Neurobiology series starts by summarizing the historical background in identifying those glycoconjugates uniquely present in neural cells. It then goes on to summarize the current theories about their roles before considering future directions in research. This book presents an outstanding summary of the latest knowledge and perspectives in neural glycobiology.
目次
- PART 1: CARBOHYDRATES OF NEURAL CELL GLYCOPROTEINS: STRUCTURE, BIOSYNTHESIS AND FUNCTION
- 1.1 Introduction
- 1.2 Core glycans of glycoproteins
- 1.3 Sulfated glycans
- 1.4 Polysialic acid in neural development
- 1.5 Sialyltransferases and polysialyltransferases
- 1.6 Mechanism of polysialic acid synthesis on NCAM
- 1.7 Control of polysialic acid expression
- 1.8 Distinct roles of polysialic acid by different polysialyltransferases: findings on gene knockout mice
- 1.9 Polysialic acid in cancer
- PART 2: POLYSIALIC ACID IN ADULT BRAIN PLASTICITY
- 2.1 Introduction
- 2.2 The role of PSA in neural development
- 2.3 The appearance of PSA-NCAM in vertebrate evolution
- 2.4 PSA expression in adult brain
- 2.5 PSA function in the adult CNS
- 2.6 PSA in pathology
- PART 3: BIOSYNTHESIS AND FUNCTION OF HNK-1 GLYCANS
- 3.1 Introduction
- 3.2 Structure
- 3.3 Expression in neural tissues
- 3.4 Developmental expression
- 3.5 Biosynthesis and regulation of expression, enzymes, cloned enzymes
- 3.6 Sulfoglucuronyl carbohydrate binding proteins
- 3.7 Immunocytochemical localization
- 3.8 Regulation of expression of sulfoglucoronyl carbohydrate, amphoterin and RAGE in retnoic acid-differentiated P19 embryonal carcinoma cells
- 3.9 Physiological role of sulfoglucuronyl carbohydrate
- PART 4: BRAIN GLYCOLIPIDS: INSIGHTS FROM GENETIC MODIFICATIONS OF BIOSYNTHETIC ENZYMES
- 4.1 Glycolipids are the predominant glycoconjungates in the brain
- 4.2 Major nervous system glycolipids
- 4.3 Target gene ablation of glycolipid biosynthetic gene
- 4.4 Summary and prospects
- PART 5: SYNTHESIS AND FUNCTION OF GLYCOSPHINGOLIPIDS
- 5.1 Introduction
- 5.2 Enzymes involved in the synthesis of glycosphingolipids
- 5.3 Roles of gangliosides elucidated with analyses of gene knockout mice
- 5.4 Modes of function of glycosphingolipids on the cell membrane
- 5.5 Redundancy of physiological function and critical roles in apoptosis
- PART 6: THE SIALIC ACID VARIETY IN GANGLIOSIDES: ORIGIN AND FUNCTION
- 6.1 Introduction
- 6.2 Chemical diversity of sialic acid
- 6.3 Metabolism of sialic acid
- 6.4 5-N-Glycosylneuraminic acid in gangliosides
- 6.5 O-Acetylated sialic acid
- 6.6 5-De-N-acetylated sialic acids in gangliosides
- 6.7 Sialic acid lactones in gangliosides
- 6.8 O-methyl sialic acids in gangliosides
- 6.9 KDN-containing gangliosides
- 6.10 Sulfated sialic acids in gangliosides
- 6.11 Internal sialic acids in gangliosides
- PART 7: DEFICICIENT GLYCOPROTEIN GLYCOSYLATION IN HUMANS AND MICE
- 7.1 Introduction
- 7.2 Mice with defects in genes required for N- and O-glycan biosynthesis
- 7.3 Human congenital diseases with defects in genes required for N- and O-glycan biosynthesis
- PART 8: LYSOSOMAL GLYCOSPHINGOLIPID STORAGE DISEASES
- 8.1 Lysosomal storage diseases
- 8.2 Glycosphingolipids
- 8.3 Mechanism of lysosomal glycosphingolipid degradation
- 8.4 Defects of glycosphingolipid catabolism
- 8.5 General aspects of sphingolipidoses
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