Health implications of perchlorate ingestion
Author(s)
Bibliographic Information
Health implications of perchlorate ingestion
National Academies Press, c2005
- : book
Available at 3 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographies references
Description and Table of Contents
Description
Perchloratea "a powerful oxidant used in solid rocket fuels by the military and aerospace industrya "has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA). The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPAa (TM)s basis. The report suggests that daily ingestion of 0.0
007 milligrams of perchlorate per kilograms of body weighta "an amount more than 20 times the reference dose proposed by EPAa "should not threaten the health of even the most sensitive populations.
Table of Contents
- 1 Front Matter
- 2 Summary
- 3 1 Introduction
- 4 2 The Thyroid and Disruption of Thyroid Function in Humans
- 5 3 Epidemiologic Studies of Occupational and Environmental Exposures to Perchlorate
- 6 4 Animal Studies
- 7 5 Risk Characterization of Perchlorate
- 8 6 Research Recommendations
- 9 Appendix A Biographic Information on the Committee to Assess the Health Implications of Perchlorate Ingestion
- 10 Appendix B Glossary
- 11 Appendix C Participants at Public Sessions
- 12 Appendix D Sensitivity of Perchlorate-Induced Iodide Uptake Inhibition to Serum Iodide Concentrations
- 13 Appendix E Physiologically Based Pharmacokinetic Modeling
by "Nielsen BookData"