Molecular chaperones and cell signalling
Author(s)
Bibliographic Information
Molecular chaperones and cell signalling
Cambridge University Press, 2005
- : hardback
Available at 5 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
Table of Contents
- Preface
- Part I. Molecular Chaperones and the Cell Stress Response: 1. Chaperone function: the orthodox view R. J. Ellis
- 2. Intracellular disposition of mitochondrial molecular chaperones: Hsp60, mHsp70, Cpn10 and TRAP-1 R. S. Gupta, T. Bowes, S. Sadacharan and B. Singh
- Part II. Changing Paradigms of Protein Trafficking and Protein Function: 3. Novel pathways of protein secretion G. Chimini and A. Rubartelli
- 4. Moonlighting proteins: proteins with more than one function C. J. Jeffery
- 5. Molecular chaperones: the unorthodox view B. Henderson and A. Shamaei-Tousi
- Part III. Molecular Chaperones as Cell Regulators: 6. Cell-cell signalling properties of chaperonins A. R. M. Coates
- 7. Toll-like receptor-dependent activation of antigen presenting cells by Hsp60, Hsp70 and Gp96 R. M. Vabulas and H. Wagner
- 8. Regulation of signal transduction by intracellular and extracellular Hsp70 A. Asea and S. Calderwood
- 9. Hsp72 and cell signalling M. Y. Sherman
- 10. Heat shock proteins, their cell surface receptors and effect on the immune system T. Lehner, Y. Wang, T. Whittall and L. A. Bergmei
- 11. Molecular chaperone-Cytokine interactions at the transcriptional level A. Stephanou and D. S. Latchman
- Part IV. Physiological and Pathophysiological Signals: 12. Heat shock protein release and naturally-occurring exogenous heat shock proteins J. Frostegard and A. G. Pockley
- 13. Hsp27 as an anti-inflammatory Protein K. Laudanski, A. De and C. Miller-Graziano
- 14. Bip, a negative immune regulator involved in rheumatoid arthritis V. M. Corrigal and G. S. Panayi
- Part V. Molecular Chaperones as Therapeutics: 15. Neuroendocrine aspects of the molecular chaperones ADNF and ADNP I. Gozes, I. Vulih, I. Spivak-Pohis and S. Furman
- 16. Heat shock proteins regulate by both molecular and network cross-reactivity F. J. Quintana and I. R. Cohen
- 17. Heat shock protein fusions: a platform for the induction of antigen-specific immunity L. Mizzen and J. Neefe
- 18. Molecular chaperones as inducers of tumour immunity P. P. Bannerjee and Z. Li
- Part VI. What Does the Future Hold?: 19. Gazing into the crystal ball: the unfolding future of molecular chaperones L. Hightower.
by "Nielsen BookData"