Brain tumors
著者
書誌事項
Brain tumors
(Contemporary cancer research / Jac A. Nickoloff, series editor)
Humana Press, c2005
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.
目次
Part I: Epidemiology, Biology, Genetics, and Pathology
Epidemiology of Brain Tumors
Randa El-Zein, Melissa Bondy, and Margaret Wrensch
Molecular Genetics of Tumors of the Central Nervous System
C. David James
Molecular Pathology of Nervous System Tumors
Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, and David N. Louis
Genetic Modeling of Glioma Formation in Mice
Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, and Eric C. Holland
Biology of Brain Metastasis
Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, and Isaiah J. Fidler
Analysis of Neural Precursor Cells in the Context of Origin of Brain Tumors, Their Treatment, and Repair of Treatment-Associated Damage
Mark Noble and Joerg Dietrich
Biology of Primitive Neuroectodermal Tumors
John R. Hill, Shoichiro Ohta, and Mark A. Israel
Part II: Mechanisms and Pathways
Molecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain Tumors
Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, and Paul van der Valk
Immune Regulation in the Brain: Lessons From Autoimmunity and Implications for Brain Tumor Therapy
Lois A. Lampson
Genetic Pathways in the Evolution of Gliomas
Hiroko Ohgaki and Paul Kleihues
DNA Damage and Repair in the Therapeutic Response of Tumors of the Central Nervous System
Henry S. Friedman, M. Eileen Dolan, and Francis Ali-Osman
Role of Urokinase-Type Plasminogen Activator Receptor in Human Glioma Invasion
Sanjeeva Mohanam and Jasti S. Rao
Regulation of Cell Cycle and Apoptosis in Human Brain Tumors
Juan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnell
Part III: Therapeutics
Systemic Chemotherapy for Metastatic Tumors of the Central Nervous System
Charles A. Conrad and W. K. Alfred Yung
Radiation Biology and Therapy of Tumors of the Central Nervous System
Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, and Dennis F. Deen
Advances in the Management of Cerebral Metastases
Fadi Hanbali and Raymond Sawaya
Immunotherapy of Central Nervous System Tumors: Contemporary Cancer Research
Amy B. Heimberger, David A. Reardon, Darell D. Bigner, and John H. Sampson
Targeting Drugs to Tumors of the Central Nervous System
Maciej S. Lesniak, James Frazier, and Henry Brem
Rational Design and Development of Targeted Brain Tumor Therapeutics
Francis Ali-Osman, Henry S. Friedman, Gamil R. Antoun, David Reardon, Darell D. Bigner, and John K. Buolamwini
Index
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