CiNii 図書 - From melanocytes to melanoma : the progression to malignancy

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

Part I. Melanocyte Development and Function The Origin and Development of Neural Crest-Derived Melanocytes Debra L. Silver and William J. Pavan MITF: A Matter of Life and Death for Developing Melanocytes Heinz Arnheiter, Ling Hou, Minh-Thanh T. Nguyen, Keren Bismuth, Tamas Csermely, Hideki Murakami, Susan Skuntz, WenFang Liu, and Kapil Bharti MITF: Critical Regulator of the Melanocyte Lineage Erez Feige, Laura L. Poling, and David E. Fisher Melanocytes and the Transcription Factor Sox10 Michael Wegner Human Cutaneous Pigmentation: A Collaborative Act in the Skin, Directed by Paracrine, Autocrine, and Endocrine Factors and the Environment Zalfa A. Abdel-Malek and Ana Luisa Kadekaro Melanocyte Distribution and Function in Human Skin: Effects of Ultraviolet Radiation Yuji Yamaguchi and Vincent J. Hearing Part II. Melanocyte Transformation and Progression to Melanoma Altered Signal Transduction in Melanoma Pablo Lopez Bergami, Anindita Bhoumik, and Ze'ev Ronai BRN2 in Melanocytic Cell Development, Differentiation, and Transformation Anthony L. Cook, Glen M. Boyle, J. Helen Leonard, Peter G. Parsons, and Richard A. Sturm The Dynamic Roles of Cell-Surface Receptors in Melanoma Development Dong Fang and Meenhard Herlyn Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation Dorothy C. Bennett Genetic Progression From Melanocyte to Malignant Melanoma Boris C. Bastian The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma Dahu Chen, Qiushi Lin, I. Saira Mian, Jon Reed, and Estela E. Medrano RB/E2F Regulation and Dual Activity in the Melanocytic System Ruth Halaban Melanoma Development and Pigment Cell Transformation Claudia Wellbrock The Biology and Genetics of Melanoma Norman E.Sharpless and Lynda Chin The Biology of Xeroderma Pigmentosum: Insights Into the Role of Ultraviolet Light in the Development of Melanoma James E. Cleaver Divergent Pathways to Cutaneous Melanoma David C. Whiteman and Adele C. Green Pigmentation, DNA Repair, and Candidate Genes: The Risk of Cutaneous Malignant Melanoma in a Mediterranean Population Maria Teresa Landi Low-Penetrance Genotypes, Pigmentation Phenotypes, and Melanoma Etiology Peter A. Kanetsky and Timothy R. Rebbeck The Biology of Melanoma Progression: From Melanocyte to Metastatic Seed A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr. Optical Imaging Analysis of Atypical Nevi and Melanoma Amanda Pfaff Smith and Dorothea Becker Proteomics Analysis of Melanoma Cell Lines and Cultured Melanocytes Katheryn A. Resing and Natalie G. Ahn Part III. Primary Invasive Melanoma to Metastatic Melanoma Paradigm of Metastasis for Malignant Melanoma Stanley P. L. Leong Repair of UV-Induced DNA Damage and Melanoma Risk Qingyi Wei High-Risk Factors for Melanoma Metastasis Neil A. Accortt and Seng-jaw Soong Role of Melanoma Inhibitory Activity in Early Development of Malignant Melanoma Anja-Katrin Bosserhoff Role and Regulation of PAR-1 in Melanoma Progression Carmen Tellez and Menashe Bar-Eli Molecular Mechanisms of Melanoma Metastasis Mohammed Kashani-Sabet Overview of Tumor Progression in Melanoma David E. Elder The Plasticity of Melanoma Cells and Associated Clinical Implications Mary J. C. Hendrix, Elisabeth A. Seftor, Angela R. Hess, and Richard E. B. Seftor The Clinical Use of Molecular Markers as Predictors of Disease Outcome and Response to Therapy in Malignant Melanoma Steve R. Martinez, Hiroya Takeuchi, Dave S. B. Hoon The Role

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From melanocytes to melanoma : the progression to malignancy

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