Embryonic stem cells : a practical approach

著者

書誌事項

Embryonic stem cells : a practical approach

edited by Elena Notarianni, Martin J. Evans

（The practical approach series）

Oxford University Press, c2006

  • : hbk
  • : pbk

大学図書館所蔵 件 / 全17件

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注記

Includes bibliographical references and index

内容説明・目次

巻冊次

: hbk ISBN 9780198550006

目次

  • Preface
  • 1 Introduction
  • 2. Procedures for deriving ES cell lines from the mouse
  • 3. Production of ES cell-derived mice
  • 4. Generating animal models of human mitochondrial genetic disease using mouse ES cells
  • 5. Controlling the differentiation of mouse ES cells in vitro
  • 6. In vitro differentiation of mouse ES cells into muscle cells
  • 7. In vitro differentiation of mouse ES cells into haematopoietic cells
  • 8. Lineage selection and transplantation of mouse ES cell-derived neural precursors
  • 9. In vitro differentiation of mouse ES cells into pancreatic and hepatic cells
  • 10. Isolation and characterisation of human ES cells
  • 11. Differentiation of human ES cells
  • 12. ES cell lines from the cynomolgus monkey (Macaca fascicularis)
  • Index
巻冊次

: pbk ISBN 9780198550013

内容説明

The groundbreaking isolation of embryonic stem cells (or 'ES cells') of the mouse in the early 1980s triggered a sustained expansion of global research into their exploitation. This led to the routine genetic engineering of the mouse and revolutionised our understanding of biological processes in the context of the whole animal. ES cell biology remains a crucial and growing area of research with far-reaching implications for developmental and comparative biology as well as for human health. This book serves as a primer to ES cells, their derivation and experimental manipulation. It contains a broad compendium of methods of direct relevance to both graduate students and specialist researchers. An introductory chapter by the principle originator of ES cell research outlines the fundamentals and charts the development of the field. This is followed by comprehensive coverage of state-of-the art techniques for ES cell manipulation, with the mouse as the experimental paradigm, and by recent innovations with ES cells from human and non-human primates. ES cell-based therapies for otherwise intractable diseases are now being developed with the present challenge to control ES cell growth and differentiation for applications such as cell transplantation - a recurrent theme in this book. As a volume in the Practical Approach Series, the emphasis is on current methods from recognised experts.

目次

  • Preface
  • 1 Introduction
  • 2. Procedures for deriving ES cell lines from the mouse
  • 3. Production of ES cell-derived mice
  • 4. Generating animal models of human mitochondrial genetic disease using mouse ES cells
  • 5. Controlling the differentiation of mouse ES cells in vitro
  • 6. In vitro differentiation of mouse ES cells into muscle cells
  • 7. In vitro differentiation of mouse ES cells into haematopoietic cells
  • 8. Lineage selection and transplantation of mouse ES cell-derived neural precursors
  • 9. In vitro differentiation of mouse ES cells into pancreatic and hepatic cells
  • 10. Isolation and characterisation of human ES cells
  • 11. Differentiation of human ES cells
  • 12. ES cell lines from the cynomolgus monkey (Macaca fascicularis)
  • Index

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