Integrative physiology in the proteomics and post-genomics age
著者
書誌事項
Integrative physiology in the proteomics and post-genomics age
Humana Press, c2005
大学図書館所蔵 全5件
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard's concept of the "milieu interieur," Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.
目次
From Functional Linkage to Integrative Physiology
Wolfgang Walz
Functional Genomics
David L. Mattson
Electrolytes and Acid-Base Physiology
Meghan M. Taylor
Circulation and Fluid Volume Control
Bruce N. Van Vliet and Jean-Pierre Montani
Neuroendocrine Networks
John A. Russell and Gareth Leng
Physiology and Behavior: Energy Balance
Michel Cabanac
Neural Circuits and Behavior
Theodore H. Bullock
Physiological Determinants of Consciousness
Mircea Steriade
Physical Activity
Frank W. Booth and P. Darrell Neufer
Biochemical Adaptation to Extreme Environments
Kenneth B. Storey and Janet M. Storey
Repair and Defense Systems at the Epithelial Surface in the Lung
Pieter S. Hiemstra
The Zebrafish As an Integrative Physiology Model
Alicia E. Novak and Angeles B. Ribera
Curriculum Design for Integrative Physiology
Dee U. Silverthorn and Penelope A. Hansen
Index
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