Integrative physiology in the proteomics and post-genomics age

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Integrative physiology in the proteomics and post-genomics age

edited by Wolfgang Walz

Humana Press, c2005

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Includes bibliographical references and index

Description and Table of Contents

Description

There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard's concept of the "milieu interieur," Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

Table of Contents

From Functional Linkage to Integrative Physiology Wolfgang Walz Functional Genomics David L. Mattson Electrolytes and Acid-Base Physiology Meghan M. Taylor Circulation and Fluid Volume Control Bruce N. Van Vliet and Jean-Pierre Montani Neuroendocrine Networks John A. Russell and Gareth Leng Physiology and Behavior: Energy Balance Michel Cabanac Neural Circuits and Behavior Theodore H. Bullock Physiological Determinants of Consciousness Mircea Steriade Physical Activity Frank W. Booth and P. Darrell Neufer Biochemical Adaptation to Extreme Environments Kenneth B. Storey and Janet M. Storey Repair and Defense Systems at the Epithelial Surface in the Lung Pieter S. Hiemstra The Zebrafish As an Integrative Physiology Model Alicia E. Novak and Angeles B. Ribera Curriculum Design for Integrative Physiology Dee U. Silverthorn and Penelope A. Hansen Index

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