Genes, environment, and psychopathology : understanding the causes of psychiatric and substance use disorders
著者
書誌事項
Genes, environment, and psychopathology : understanding the causes of psychiatric and substance use disorders
Guilford Press, c2006
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注記
Includes bibliographical references (p. 351-376) and indexes
内容説明・目次
内容説明
This groundbreaking volume synthesizes the results of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, which yielded longitudinal data on more than 9,000 individuals. The authors trace how risk for depression, anxiety, eating disorders, antisocial behavior, alcoholism, and substance abuse emerges from the interplay of a variety of genetic and environmental influences. Major questions addressed include whether risk is disorder-specific, how to distinguish between correlational and causal genetic and environmental factors, sex differences in risk, and how risk and protective factors interact over time. The book also summarizes the conceptual underpinnings of the study and describes key methodological challenges and innovations.
目次
Introduction. Part I: Background. The Scientific and Social Context of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. Methodology Used in the VATSPSUD. Twinning and Twin Models. Part II: Genetic Risk. Internalizing Disorders. Externalizing and Substance Use Disorders. Twin Model Assumptions. Part III: Environmental Risk. Childhood Experiences and Risk for Psychopathology. Adult Experiences and Risk for Psychopathology. Part IV: A Closer Look at Genetic and Environmental Influences. Sex Differences. Genetic and Environmental Influences on Stability and Change. The Genetics of What?: Comorbidity, General versus Specific Effects, and Intermediate Phenotypes. Three Extensions of the Twin Model. Part V: Bringing it all Together. The Genetics of the Environment. Mechanisms for Genetic Control of Exposure to the Environment. Is the Relation Between Environmental Risk Factors and Psychiatric Disorders Causal? Genetic Control of Sensitivity to the Environment.. Integrative Models. Conclusions.
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