ADME-Tox approaches
著者
書誌事項
ADME-Tox approaches
（Comprehensive medicinal chemistry II / editors-in-chief John B. Taylor, David J. Triggle, v. 5）
Elsevier, 2007
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
To be effective a drug must be Absorbed then Distributed to the site of action. It must also be Metabolised and Excreted without any measurable Toxicity (ADMET). This volume examines major ADMET issues, tools to measure these properties in vivo and in vitro and in-silico tools to predict and analyse effects. It concludes with a review of tools that can assist drug discovery in its early development stage.
目次
Volume 5 ADME-Tox Approaches Introduction Biological and In Vivo Aspects of Absorption, Distribution, Metabolism, Excretion, and Toxicity Biological In Vitro Tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity Physicochemical tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity In Silico Tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity Enabling Absorption, Distribution, Metabolism, Excretion, and Toxicity Strategies and Technologies in Early Development
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