Crossroads between innate and adaptive immunity

著者

書誌事項

Crossroads between innate and adaptive immunity

Peter D. Katsikis, Bali Pulendran, Stephen P. Schoenberger, editors

（Advances in experimental medicine and biology, v. 590, 633, 780, 785, 850）

Springer : Aegean Conferences, c2007-

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"Proceedings of the 'First Crossroads Between Innate and Adaptive Immunity' Conference, held in Rhodes, Greece, October 9-14, 2005."--T.p. verso of v. [1]

"This compilation contains minireviews derived from work presented at the Aegean Conference: 'Second Crossroads between Innate and Adaptive Immunity,' which took place from June 17 to 22, 2007 at the Aldemar Knossos Royal Village on the island of Rhodes, Greece."--P. v of v. 2

"This volume presents a collection of reviews derived from work presented at the Aegean Conference, '3rd Crossroads between Innate and Adaptive Immunity,' which occured from September 27 to October 2, 2009 at the Minoa Palace Conference Cetner in Chania, Crete, Greece."--P. v of v. 3

"The reviews included in this volume are based on the work presented at the Aegean Conference '4th Crossroads between Innate and Adaptive Immunity,' which occured between September 11 and September 16, 2011, at the Royal Myconian Conference Center in Elia, Mykonos, Greece."--P. v of v. 4

Includes bibliographical references and index

内容説明・目次

巻冊次

[1] ISBN 9780387348131

内容説明

This compilation presents mini-reviews derived from work presented at the Aegean Conference: "First Crossroads between Innate and Adaptive Immunity," which occurred in October, 2005 at the Hilton Conference Center on the island of Rhodes, Greece. The conference included sessions dedicated to host recognition of and response to pathogens, innate immune networks, antigen presentation, and adaptive immune responses, each headlined by a leading scientist.

目次

Signal Transduction in DC Differentiation: Winged Messengers and Achilles' Heel.- Shaping Naive and Memory Cd8+ T Cell Responses in Pathogen Infections Through Antigen Presentation.- Understanding the Role of Innate Immunity in the Mechanism of Action of the Live Attenuated Yellow Fever Vaccine 17D.- The Function of Local Lymphoid Tissues in Pulmonary Immune Responses.- The Yin and Yang of Adaptive Immunity in Allogeneic Hematopoietic Cell Transplantation: Donor Antigen-Presenting Cells Can Either Augment or Inhibit Donor T Cell Alloreactivity.- It's Only Innate Immunity But I Like it.- Innate Tumor Immune Surveillance.- Regulation of Adaptive Immunity by Cells of the Innate Immune System: Bone Marrow Natural Killer Cells Inhibit T Cell Proliferation.- Induction and Maintenance of Cd8+ T Cells Specific for Persistent Viruses.- Germinal Center-Derived B Cell Memory.- CD28 and Cd27 Costimulation of Cd8+ T Cells: A Story of Survival.- CD38: An Ecto-Enzyme at the Crossroads of Innate and Adaptive Immune Responses.- Vascular Leukocytes: a Population with Angiogenic and Immunossuppressive Properties Highly Represented in Ovarian Cancer.- CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells.- Receptors and Pathways in Innate Antifungal Immunity.
巻冊次

2 ISBN 9780387793108

内容説明

Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. This volume will include mini-reviews derived from work to be presented at the Aegean Conference: Second Crossroads between Innate and Adaptive Immunity, in Crete, Greece, June 17-22, 2007. This meeting is designed to serve as a forum to discuss the most recent progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of development in complement basic research and the advent and application of new experimental approaches in this field have now allowed us to take an integrated view of the in vivo biology of the complement system. The availability of new reagents (e.g. synthetic and recombinant inhibitors) and animal models (e.g. transgenic and knockout mice) has enabled us to address, in an in vivo setting, its involvement in various pathophysiological conditions. Such studies are shedding new light on the pathogenetic mechanism of complement-related diseases such as autoimmune diseases and inflammatory tissue damage as well as defining new areas of high interest such as the developmental biology of complement. They also provide the basis for developing new therapeutic strategies for these diseases through manipulation of in vivo complement activity. This volume will serve as a resource where the latest development in these specific areas will be discussed in a more focused and detailed manner.

目次

THE PROTECTIVE EFFECTS OF TYPE-1 INTERFERON IN MODELS OF INTESTINAL INFLAMMATION.- THE NK/DC COMPLOT.- DETECTION OF MICROBES BY NATURAL KILLER T CELLS.- ONTOGENY OF THE SECONDARY ANTIBODY RESPONSE: ORIGINS AND CLONAL DIVERSITY.- THE ROLE OF PI3K SIGNALLING IN THE B CELL RESPONSE TO ANTIGEN.- CD28 - OLD DOG, NEW TRICKS: CD28 IN PLASMA CELL/MULTIPLE MYELOMA BIOLOGY.- Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection.- EFFECTS OF CANCER IMMUNOTHERAPY REGIMENS ON PRIMARY VERSUS SECONDARY IMMUNE RESPONSES AND THE POTENTIAL IMPACT ON LONGTERM ANTI-TUMOR RESPONSES.- NEW INSIGHTS INTO CLASSICAL COSTIMULATION OF CD8+ T CELL RESPONSES..- PERIPHERAL TOLERANCE INDUCTION BY LYMPH NODE STROMA.
巻冊次

3 ISBN 9781441956316

内容説明

This volume presents a collection of reviews derived from work presented at the Aegean Conference: "3rd Crossroads between innate and adaptive immunity" which occurred during September 27 - October 2, 2009 at the Minoa Palace Conference Center in Chania, Crete, Greece. This meeting was the third in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The various facets of the innate response, including dendritic cells, T cells, B cells, NK cells, NK-T cells and the complement cascade during the host response to pathogens and tumors is only now starting to be elucidated. The respective fields that focus on these immune cells and molecules have tended to be relatively compartmentalized, and yet emerging evidence points to the interconnectedness of these facets in coordinating the innate response, and its subsequent impact on the adaptive response. The goal of this conference was to initiate cross-talk between these diverse immunological fields, and promote and facilitate discussion on the interactions between the innate immune response and the adaptive immune response and ultimately facilitate collaboration between these areas of study. Following on the footsteps of the outstanding success of its precursors, the "3rd Crossroads between Innate and Adaptive Immunity" Aegean Conference was highly successful in bringing together and connecting scientists and experts from around the world to address critical areas of Innate and Adaptive immunity.

目次

Is Transcription the Dominant Force during Dynamic Changes in Gene Expression?.- MicroRNAs: Key Components of Immune Regulation.- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV.- Natural Killer cell Licensing during Viral Infection.- Bridging Innate NK cell Functions with Adaptive Immunity.- Control of Innate Immunity by Memory CD4 T cells.- Strategies and Implications for Prime-Boost Vaccinations to Generate Memory CD8 T Cells.- Blimp1: Driving Terminal Differentiation to a T.- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis.- Impact of Differential Glycosylation on IgG Activity.- Murine Model of Chronic Respiratory Inflammation.- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1.- Influenza Vaccines: What do we Want and How can we Get it?.
巻冊次

4 ISBN 9781461462163

内容説明

This volume presents a collection of reviews derived from work presented at the Aegean Conference: "4th Crossroads between innate and adaptive immunity". This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference "Crossroads between Innate and Adaptive Immunity" brought together leading international scientists and experts to address critical areas of Innate and Adaptive immunity something necessary for the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive immunity. The conference had limited participation and a scientific and social program that maximized scientific interchange through lecture presentations, poster sessions and informal discussions.

目次

Is Transcription the Dominant Force during Dynamic Changes in Gene Expression?.- MicroRNAs: Key Components of Immune Regulation.- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV.- Natural Killer cell Licensing during Viral Infection.- Bridging Innate NK cell Functions with Adaptive Immunity.- Control of Innate Immunity by Memory CD4 T cells.- Strategies and Implications for Prime-Boost Vaccinations to Generate Memory CD8 T Cells.- Blimp1: Driving Terminal Differentiation to a T.- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis.- Impact of Differential Glycosylation on IgG Activity.- Murine Model of Chronic Respiratory Inflammation.- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1.- Influenza Vaccines: What do we Want and How can we Get it?.
巻冊次

5 ISBN 9783319157733

内容説明

This volume presents a collection of reviews derived from work presented at the Aegean Conference: "5th Crossroads Between Innate and Adaptive Immunity". This meeting was the fifth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference "Crossroads between Innate and Adaptive Immunity" brought together leading international scientists and experts to address critical areas of Innate and Adaptive Immunity, a necessary step in the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive Immunity, and maximized scientific interchange through lecture presentations, poster sessions and informal discussions.

目次

Type III IFNs: Emerging Master Regulators of Immunity.- Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines.- The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses.- Functional Diversity of Human Dendritic Cells.- Selective Dependence of Kidney Dendritic Cells on CX3CR1: Implications for Glomerulonephritis Therapy.- Mechanisms of Memory T Cell Activation and Effective Immunity.- Molecular Programming of Immunological Memory in Natural Killer Cells.- Induction of Immune Tolerance to Dietary Antigens.- The Role of p110 in the Development and Activation of B Lymphocytes.- Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model.

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