Inhalation toxicology

Author(s)

    • Salem, Harry
    • Katz, Sidney A.

Bibliographic Information

Inhalation toxicology

edited by Harry Salem, Sidney A. Katz

CRC/Taylor & Francis, c2006

2nd ed

Available at  / 1 libraries

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Note

Includes bibliographical references and index

HTTP:URL=http://www.loc.gov/catdir/enhancements/fy0648/2005051482-d.html Information=Publisher description

Description and Table of Contents

Description

Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances and examine methods and measurements for improving our understanding of the basic mechanisms of effects. The book delineates key issues in the field such as regulatory aspects of exposure and testing, testing equipment and methods, biomarkers, pathology, allergies and immunology, irritation of the respiratory tract, and risk assessment. It covers the inhalation of bioaerosols and toxins, ranging from anthrax to household molds as well as genomics, proteomics, and low-level exposure toxicants such as tobacco smoke and chemical warfare agents. Highlights include coverage of the Acute Exposure Guidelines and Emergence Response Guidelines and recent changes in the European and American guidelines for testing procedures. The book focuses on key issues associated with airborne substances and provides critical reviews of the latest advances. Presenting sophisticated concepts in a readable, accessible format, the book distills the latest information into practical knowledge.

Table of Contents

INHALATION METHODS AND MEASUREMENTS Inhalation Risk Assessment at the Environmental Protection Agency, J.E. Whalan, G.L. Foureman, and J.J. Vandenburg The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances, G.M. Rush Emergency Response Planning Guidelines (ERPGs), F. Cavender Directed Flow Aerosol Inhalation Exposure Systems: Application to Pathogens and Highly Toxic Agents, R.J. Jaeger, S.G. Shami, and L. Tsenova Whole-Body, Low-Level Sarin Vapor Exposure in Rats: Estimating the Probability of Miosis as a Function of Exposure Concentration and Duration, R.J. Mioduszewski, R.G. Crosier, W.T. Muse, Jr., D.R. Sommerville, and S.A. Thomson Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example, D.W. Porter and A.F. Hubbs The Use of Large Animals in Inhalation Toxicology, R.F.R. Brown, B.J.A. Jugg, and J. Jenner Toxic Load Modeling, D.R. Sommerville, K.H. Park, M.O. Kierzewski, M.D. Dunkel, M.I. Hutton, and N.A. Pinto Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program, E.K. Weisburger and V.W. Hudson Combustion Toxicology, B. Levin INHALATION TOXICOLOGY MECHANISMS Toxicogenomics of Low-Level Nerve Agent Vapor Exposure, J.W. Sekowski Respiratory Sensitization, M. Blackwell Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure, B. Ballantyne Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles, F. Huaux Hormesis: Implications for Risk Assessment, E. Calabrese Nasal Toxicology, J.B. Morris Effects of Inhaled Toxicants on the Nose and Nasal Function, P. Dalton and R. Opiekun Toxicokinetics: Deposition, Absorption, Distribution, and Excretion, M.A. Inchiosa, Jr. Pharmacokinetics of Hydrocarbons and Mixtures, K. Krishnon Inhalation Toxicology of an Irritant Gas: Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure, A.M. Sciuto Inhalation Toxicology of Riot Control Agents, H. Salem, B. Ballantyne, and S.A. Katz Chemical Warfare Agents and Nuclear Weapons, N.M. Elsayed and H. Salem Inhalation Toxicology of Metals (Chromium), S.A. Katz and H. Salem Safety Assessment of Therapeutic Agents Administered by the Inhalation Route, S. Gad Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract, G.L. Finch INHALATION TOXICOLOGY OF MATERIALS Inhalation Toxicology of Alcohol/Gasoline Fuels: Current Status, R. Poon Asbestos, D.M. Bernstein The Inhalation Toxicity of Benzene, R. Synder and M. von Raaij Carbon Monoxide, J.J. McGrath Experimental, Clinical, Occupational Toxicology and Forensic Aspects of Hydrogen Cyanide and Particular Reference to Vapor Exposure, B. Ballantyne and H. Salem The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans, S.R. Lane, P.J. Nichols, and R.D.E. Sewell Fluorocarbon Alternatives: Methodologies for Special Studies and Results, D.E. Dodd and W.J. Brock Animal Models for Three Major Cigarette-Smoke-Induced Diseases, R.R. Schleef, P.M. Vanscheeuwijik, W.K. Schlage, J.F. Borelleca, C.R.E. Coggins, and H-J. Haussmann The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health, S-J.T. Todd and S.T. Omaye INHALATION TOXICOLOGY OF BIOLOGICALS Health Aspects of Bioaerosols, K.P. O'Connell and H. Salem Emerging Biothreats: Natural and Deliberate, J.M. Mann and N.D. Connell Toxicology Associated with Respiratory Exposures to Fungi (Molds), M.D.W. Ward, Y.J. Chung, and M.J.K. Selgrade Inhalation of Botulinum Toxins, M. Adler Inhalation of Ricin: Aerosol Procedures, Animal Toxicology, and Therapy, R.W. Wannemacher, Jr. and H.B. Anderson Inhalation Toxicology & Phamacology of Biologicals and Toxins: Prophylaxis and Therapy, B. Paddle

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