Biology of depression
著者
書誌事項
Biology of depression
Wiley-VCH-Verl, c2005
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene--environment interactions. This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.
目次
Preface.List of Contributors.Abbreviations.1 Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10 (Alan M. Gruenberg, Reed D. Goldstein and Harold Alan Pincus).2 Psychosocial and Environmental Formulations of Depression (Gordon Parker and Kay Parker).3 The Economic Burden of Depression: Societal and Patient Perspectives (Paul E. Greenberg and Howard G. Birnbaum).4 The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions (Hagop S. Akiskal and Lewis L. Judd).5 The Monoamine Hypothesis of Depression (Leslie Iversen).6 Monoaminergic-based Pharmacotherapy for Depression (George I. Papakostas and Maurizio Fava).7 Psychobiology of Electroshock (Max Fink).8 Current Prognosis of Depression (H. Brent Solvason and Alan Schatzberg).9 Treatment of Depression in Medical Illness (Charles L. Raison, David C. Purselle, Lucile Capuron and Andrew H. Miller).10 Depression and Suicidality in Children and Adolescents (Cynthia R. Pfeffer).11 The Biology and Genetics of Suicidality (Gustavo Turecki and Aleksandra Lalovic).12 Geriatric Depression (Bindu Shanmugham and George Alexopoulos).13 Comorbidity of Depression and Substance Abuse (Edward V. Nunes and Wilfred N. Raby).14 Depression in the Context of Cancer (Elliot J. Coups, Jeremy Winell and Jimmie C. Holland).15 Treatment of Refractory Depression (Michael Gitlin).16 Clinical Pharmacology of New Classes of Antidepressant Drugs (Justine M. Kent).17 Neuroimaging and Neuropathological Studies of Mood Disorders (Wayne C. Drevets and Joseph L. Price).18 Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms (Blynn G. Bunney, Steven G. Potkin and William E. Bunney).19 Neuropeptidergic Dysfunction in Depression (Garth Bissette).20 Depression, Mania, and Thyroid Function: A Story of Intimate Relationships (Peter C. Whybrow and Michael Bauer).21 Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities (P. W. Gold).22 Neuroimmune Mediators: Are Cytokines Mediators of Depression? (Renaud de Beaurepaire, Artur H. Swiergiel and Adrian J. Dunn).23 Borna Disease Virus: Impact on Mood and Cognition (Liv Bode, Detlef E. Dietrich and Hanns Ludwig).24 Depression and Heart Disease (Robert M. Carney and Kenneth E. Freedland).25 Genetic Substrates Shared by Depression and Cardiovascular Disease (Brigitta Bondy).26 History and Epidemiology of Depression (Ma-Li Wong).27 Major Depression and Animals Models (Ma-Li Wong).28 Loss and Deprivation: From Animal Models to Clinical Presentation (Kristin M. Penza, Christine Heim and Charles B. Nemeroff).29 Neurogenomics of depression (Klaus Peter Lesch).30 Genetic Approaches to Depression: Linkage Studies (Francis M. Mondimore and James B. Potash).31 Genetic Approaches to Depression: Association Studies (Kopal Tandon and Katherine J. Aitchison).32 Molecular Effects of Antidepressant Treatments (Pierre Sokoloff).33 The Role of Transcription Factors in the Biology of Depression (Robert D. Beech and Ronald S. Duman).34 Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action (Ma-Li Wong).35 Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications (Adrian Llerena).36 Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response (Kristopher J. L. Irizarry).37 Emerging Treatments for Depression: Beyond the Monoamine Hypothesis (Julio Licinio).38 Antidepressants and Suicide: Clinical Considerations (Julio Licinio).39 Depression in Developing Countries (Mauricio Silva de Lima and Bernardo Garcia de Oliveira Soares).40 Complementary and Alternative Medical Treatment for Depression (Peter B. Bongiorno).41 The Experience of Depression (Susan Blauner, Catherine Bond, Philip J. Burguieres, Ma-Li Wong, Julio Licinio, and Deborah L. Flores).Subject Index.
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