Evolutionary bioinformatics
著者
書誌事項
Evolutionary bioinformatics
Springer, c2006
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注記
Includes bibliographical references (p. [361]-391) and index
内容説明・目次
内容説明
Books on bioinformatics, which began appearing in the mid 80s primarily served gene-hunters, and biologists who wished to construct family trees showing tidy lines of descent. Given the great pharmaceutical industry interest in genes, this trend has continued in most subsequent texts. These deal extensively with the exciting topic of gene discovery and searching databases, but hardly consider genomes as information channels through which multiple forms and levels of information, including genic information, have passed through the generations. This book identifies the types of information that genomes transmit, shows how competition between different types is resolved in the genomes of different organisms, and identifies the evolutionary forces involved. The early chapters relate the form of information with which we are most familiar, namely written texts, to the DNA text that is our genome. This lends itself well to introducing historical aspects dating back to the nineteenth century.
目次
Prologue.- Part 1: Memory-A Phenomenon of Arrangement.- Chargaff's First Parity Rule.- Information Levels and Barriers.- Part 2: Chargaff's Second Parity Rule.- Stems and Loops.- Chargaff's Cluster Rule.- Part 3: Mutation and Speciation.- Species Survival and Arrival.- Chargaff's GC Rule.- Part 4: Conflict with Genomes.- Conflict Resolution.- Exons and Introns.- Complexity.- Part 5: Conflict Between Genomes.- Sef/Not-Self?- The Crowded Cytosol.- Part 6: Sex and Error-Correction.- Rebooting the Genome.- The Fifth Letter.- Epilogue.- Appendix 1: What the Graph Says.- Appendix 2: Scoring Information Potential.- Appendix 3: No Line?- Acknowledgements.- References and Index.
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