The serotonin receptors : from molecular pharmacology to human therapeutics

著者

    • Roth, Bryan L.

書誌事項

The serotonin receptors : from molecular pharmacology to human therapeutics

edited by Bryan L. Roth

（Receptors）

Humana Press, c2006

大学図書館所蔵 件 / 全7件

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注記

Includes bibliographical references and index

HTTP:URL=http://www.loc.gov/catdir/toc/ecip061/2005029055.html Information=Table of contents only

内容説明・目次

内容説明

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

目次

Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors Wesley K. Kroeze and Bryan L. Roth Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes Richard B. Westkaemper and Bryan L. Roth Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure: Functional and Pathological Implications, Marilyn A. Davies, Chiao-ying Chang, and Bryan L. Roth Strategies for the Development of Selective Serotonergic Agents Richard A. Glennon 5-HT Receptor Signal Transduction Pathways John R. Raymond, Justin H. Turner, Andrew K. Gelasco, Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur, and Maria N. Garnovskaya Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction Kelly A. Berg and William P. Clarke Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins: A Proteomic Approach Joel Bockaert, Carine Becamel, Lara Joubert, Sophie Gavarini, Aline Dumuis, and Philippe Marin 5-HT Receptor-Associated Proteins (FRAPs): Relevance for Targeting, Trafficking, and Signal Transduction Zongqi Xia, Douglas J. Sheffler, and Bryan L. Roth Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System Laurent Descarries, Virginia Cornea-Hebert, and Mustapha Riad Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain Guadalupe Mengod, M. Teresa Vilaro, Roser Cortes, Juan F. Lopez-Gimenez, Andreu Raurich, and Jose M. Palacios Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors Pau Celada, Albert Adell, and Francesc Artigas Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions Evelyn K. Lambe and George K. Aghajanian The Emergence of 5-HT2B Receptors as Targets toAvoid in Designing and Refining Pharmaceuticals Vincent Setola and Bryan L. Roth The 5-HT3 Receptor Andrew J. Thompson, Li Zhang, and Sarah C. R. Lummis 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia Frank Lezoualc'h and Magali Berthouze Electrophysiological Properties of Gas-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7) Rodrigo Andrade 5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia Rudy Schreiber, Andrew Sleight, and Marie Woolley 5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery Peter B. Hedlund and J. Gregor Sutcliffe Serotonin System Gene Knockouts: A Story of Mice With Implications for Man Miles Berger and Laurence H. Tecott Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission Anita J. Bechtholt and Irwin Lucki Index

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