The neurobiology of epilepsy and aging
著者
書誌事項
The neurobiology of epilepsy and aging
（International review of neurobiology, v. 81）
Elsevier Academic Press, c2007
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume in the International Review of Neurobiology series addresses the epidemiology, pathophysiology, and treatment of epilepsy in elderly patients. Demographically, the elderly comprise both the fastest-growing segment of the U.S. population and the adult age group with the highest incidence of epilepsy, yet there are relatively few publications devoted to this clinical subgroup. The intersection of these two complex processes-epilepsy and advancing age-will have an increasing impact on medical and community care. The etiology, prognosis, and differential diagnosis of epilepsy can all be affected by the normal aging process and by the frequent comorbidities encountered in an elderly population. Chapters in this book review the effects of aging on brain function and on drug metabolism and interactions, covering the gamut of research from animal models of aging and epilepsy to clinical trials and outcomes. Topics also include the dangers of misdiagnosing status epilepticus, the special issues encountered in recruiting and retaining elderly clinical trial participants, and the use of antiepileptic drugs in the elderly. In both the clinic and the research laboratory, a better understanding of how epilepsy may differ between younger and older patients will be valuable in determining the best possible care for geriatric patients with epilepsy.
目次
Epilepsy in the Elderly: Scope of the Problem
Animal Models in Gerontology Research
Animal Models of Geriatric Epilepsy
Life and Death of Neurons in The Aging Cerebral Cortex
An in vitro model of Stroke-Induced Epilepsy: Elucidation of The roles of Glutamate and Calcium in The induction and Maintenance of Stroke-Induced Epileptogenesis
Mechanisms of Action of Antiepileptic Drugs
Epidemiology and Outcomes of Status Epilepticus in The Elderly
Diagnosing Epilepsy in the Elderly
Pharmacoepidemiology in Community-Dwelling Elderly Taking Antiepileptic Drugs
Use of Antiepileptic Medications In Nursing Homes
Age-Related Changes in Pharmacokinetics: Predictability and Assessment Methods
Factors affecting Antiepileptic Drug Pharmacokinetics in Community-Dwelling Elderly
Pharmacokinetics of Antiepileptic Drugs in Elderly Nursing Home Residents
The Impact of Epilepsy on Older Veterans
Risk and Predictability of Drug Interactions in the Elderly
Outcomes in Elderly Patients With Newly Diagnosed and Treated Epilepsy
Recruitment and Retention in Clinical trials of The Elderly
Treatment of Convulsive Status Epilepticus
Treatment of Nonconvulsive Status Epilepticus
Antiepileptic Drug Formulation and Treatment in the Elderly: Biopharmaceutical Considerations
Index
Contents of Recent Volumes
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