書誌事項

Recent advances in the chemistry of β-lactam antibiotics

the proceedings of the Fourth International Symposium, organized by the Fine Chemicals and Medicinals Group of the Industrial Division of the Royal Society of chemistry, Cambridge, England, 3rd--6th July 1988 ; edited by P. H. Bentley, R. Southgate

(Special publication / Royal Society of Chemistry, no. 70)

Royal Society of Chemistry, c1989

タイトル別名

Recent advances in the chemistry of [beta]-lactam antibiotics

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内容説明・目次

内容説明

A collection of papers from a conference on B-lactam antibiotics in which the contributors discuss the progress of scientific understanding of the synthesis, biosynthesis and structure activity relationships amongst this group, as well as the importance of B-lactamases in bacterial resistance.

目次

  • Recent advances in the biosynthesis of penicillins and cephalosporins, J.E.Baldwin
  • carbapenem and carbapenam biosynthesis in "Serratia" and "Erwinia" species, B.W.Bycroft
  • A-cyclopenams - the synthesis and activity of a new class of penam antibacterials, J.Christenson et al
  • new developments in the synthesis and SAR of several series of 2-aminothiazolyl cephalosporins, W.Durckheimer et al
  • synthesis, biological properties and pharmacokinetics of 7432-S, a new oral cephem, Y.Hamashima
  • synthesis of bicyclic B-lactams involving free-radical reactions, M.D.Bachi
  • synthesis and X-ray crystal structure determination of 1,3-bridged B-lactams - novel anti-Bredt B-lactams, R.M.Williams et al
  • lactivicin, a new type of B-lactam-like antibiotic from bacteria - chemistry and biological activity, Y.Nakao
  • synthesis and biological evaluation of pyrazolidinone antibacterial agents, R.J.Ternansky and S.E.Draheim
  • synthesis of potential inhibitors of bacterial D, D-peptidases, J.Marchand-Brynaert et al
  • novel carbapenems, T.N.Salzmann et al
  • a novel Diels-Alder approach to carbapenems, R.Bayles et al
  • penicillin and cephalosporins - their biosynthetic enzymes, R.D.G.Cooper
  • 6-hydroxyethyl penems - ten years after, G.Franceschi et al
  • synthesis and B-lactamase inhibitory activity of 6-substituted methylene penems, N.J.P.Broom et al
  • a new synthesis of penems, A.J.Barker and M.J.Jenkins
  • methodology for the design, synthesis and study of new B-lactam antibiotics, M.J.Miller et al
  • radical approaches to the synthesis of B-lactam antibiotics, J.Knight and P.J.Parsons
  • an efficient synthesis of (3R, 4R)-3-(1(R)-hydroxyethyl)-4-(benzoyloxy)-2-azetidinone from L-threonine and use of phenylalkoxymethyl as a novel N-protecting group, A.Afonso et al
  • the biosynthesis of clavulanic acid, S.W.Elson
  • class C B-lactamases - molecular and kinetic characteristics, J.M.Frere et al
  • synthesis and evaluation of a new series of 3-acyl-1-carbacephalosporins, J.A.Eudaly et al
  • synthesis and antibacterial activity of isocephems, J.Aszodi et al
  • cephalosporins - themes and variations, C.E.Newall.

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