Evolving methods for macromolecular crystallography : the structural path to the understanding of the mechanism of action of CBRN agents
著者
書誌事項
Evolving methods for macromolecular crystallography : the structural path to the understanding of the mechanism of action of CBRN agents
（NATO science series, Sub-series II . Mathematics,
Springer, c2007
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注記
"Proceedings of the NATO Advanced Study Institute on Evolving Methods for Macromolecular Gystallography : the Structural Path to the Understanding of the Mechanism of Action of CBRN agents, Erice, Italy 19-28 May 2005" -- T. p. verso
内容説明・目次
内容説明
This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis. The book shows how modern high-throughput methods are contributing to a deeper understanding of medical problems.
目次
- Preface. Succeeding with Seeding: some practical Advice
- T. Bergfors.- Expression, Purification and Crystallisation of membrane Proteins
- Bernadette Byrne.- Macromolecular Cryo-Crystallography
- E. Garinan.- Processing Diffraction Data with Mosfim
- A.G. W. Leslie and H.R. Powell.- SAD Phasing: basic Concepts and High-Throughput
- G.M. Sheldrick.- Likelihood-based experimental phasing in Phaser
- A.J. McCoy, L. C. Storoni and R. J. Read.- Stochastic molecular Replacement
- N. M. Glykos.- Likelihood-based molecular Replacement in Phaser
- R. J. Read et al.- Automated Structure Determination with PHENIX
- P. D. Adam et al.- Density Modification in MAIN
- D. Turk.- Ab initio Phasing starting from Low Resolution
- V.Lunin et al. Structural Genomics of Mycobacterium tuberculosis - a Search for Function and new Drug Targets
- T. Baker.- 3D Domain Swapping and its Relevance to conformational Diseases
- M. Jaskolski.- Structural Bioinformatics: From PROTEIN Structure to Function
- J.D. Watson et al.- Single-particle Imaging
- D. Sayre.-
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