Current topics in innate immunity
著者
書誌事項
Current topics in innate immunity
（Advances in experimental medicine and biology, v. 598,
Springer, c2007-
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注記
"Aegean Conferences"
"Proceedings from the 4th International Conference on Innate Immunity held in Corfu, Greece, June 4-9, 2006."--T.p. verso
"This volume contains the latest advances ... as presented ... at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece"--Back cover of II. Held in 2010
Eitors of II: John D. Lambris, George Hajishengallis
Includes bibliographical references and index
内容説明・目次
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[1] ISBN 9780387717654
内容説明
In the post genomic era, understanding of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. This volume covers natural killer cells, mast cells, phagocytes, toll-like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches.
目次
Toll-like Receptors, Natural Killer Cells and Innate Immunity.- In the Thick of the Fray: NK Cells in Inflamed Tissues.- Structural Insight into Natural Killer T Cell Receptor Recognition of CD1d.- The Journey of Toll-like Receptors in the Cell.- Differential Regulation of Key Signaling Molecules in Innate Immunity and Human Diseases.- Systems Biology of Macrophages.- The Alternative Pathway of Complement: a Pattern Recognition System.- Role of MBL-associated Serine Protease (MASP) On Activation of the Lectin Complement Pathway.- Viral Heparin-Binding Complement Inhibitors - A Recurring Theme.- C3a Receptors Signaling in Mast Cells.- Antimicrobial C3a -Biology, Biophysics, and Evolution.- C5L2 - an Anti-inflammatory Molecule or a Receptor for Acylation Stimulating Protein (C3a-desArg)?.- The Exosporium of B.cereus Contains a Binding Site for gC1qR/p33: Implication in Spore Attachment and/or Entry.- Immunity in Borreliosis with Special Emphasis on the Role of Complement.- Murine CR1/2 Targeted Antigenized Single-Chain Antibody Fragments Induce Transient Low Affinity Antibodies and Negatively Influence an Ongoing Immune Response.- The Third Complement Component as Modulator of Platelet Production.- In Vivo Biological Responses in the Presence or Absence of C3.- Complement Activation of Drusen in Primate Model (Macaca fascicularis) for Age-Related Macular Degeneration.- Exploring the Complement Interaction Network Using Surface Plasmon Resonance.- Glycosylation as a Target for Recognition of Influenza Viruses by the Innate Immune System.- Immune Effects of Autoantigen-Associated RNA.- Induction and Evasion of the Type I Interferon Response by Cytomegaloviruses.- Pore Formers of the Immune System.- Pathogen-Specific Innate Immune Response.- Flagellin Signalling in Plant Immunity.- Ancient Origin of the Complement System: Emerging Invertebrate Models.- Biological Roles of Lectins in Innate Immunity: Molecular and Structural Basis for Diversity in Self/Non-Self Recognition.- Hydrogen/Deuterium Exchange Mass Spectrometry:Potential for Investigating Innate Immunity Proteins.
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2 ISBN 9781461401056
内容説明
Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense.
This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.
目次
Pentraxins in humoral innate immunity.- galectins as pattern recognition receptors: structure, function, and evolution.- the role of innate immunity in trafficking of hematopoietic stem cells - an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids.- interaction of the microbiome with the innate immune response in chronic wounds.- keystone species and community service through manipulation of innate immunity.- a conserved host and pathogen site on immunoglobulins: structural and functional aspects.- advances in understanding the structure, function, and mechanism of the scin and efb families of staphylococcal immune evasion proteins.- granzyme b: a new crossroad of complement and apoptosis.- role of c3, c5 and anaphylatoxin receptors in acute lung injury and in sepsis.- complement mediated ocular angiogenesis.- platelets, complement, and contact activation: partners in inflammation and thrombosis.- nuclear factor- b in immunity and inflammation: the treg and th17 connection.- function of act1 in il-17 family signaling and autoimmunity.- differential effect of inhibiting md-2 and cd14 on lps- versus whole e. coli bacteria-induced cytokine responses in human blood.- zebrafish: model for the study of inflammation and the innate immune response to infectious diseases.- monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection.- nk/dc crosstalk in anti-viral response.- innate-adaptive crosstalk: how dendritic cells shape immune responses in the cns.- nutritional immunity: homology modeling of nramp metal import.
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