Synthetic vaccines
著者
書誌事項
Synthetic vaccines
Blackwell Scientific Publications, c1994
大学図書館所蔵 全1件
注記
Includes bibliographical references (p. 527-531) and index
内容説明・目次
内容説明
This handbook covers the experimental basis and essential steps involved in the construction of a synthetic vaccine - from the initial determination of the antigenic sites, through chemical or recombinant DNA directed synthesis, to the use of engineered viruses. Chapters are also devoted to antigenicity of carbohydrate structures and anti-idiotype vaccines. A general outline of the immune system has been included for those unfamiliar with this aspect and as an introduction to the detailed consideration in later chapters of the mechanisms and molecules involved, including cell-mediated immunity, antibody structure, processing and presentation of antigen, peptide structure in solution and how these molecules are recognised. The latter part of the book illustrates these techniues and some of the problems encountered in their application to six well-known diseases - malaria, foot and mouth disease, hepatitis, AIDS, influenza and polio.
目次
- Outline of the components of an immune response
- general features of the structure of immunoglobulins
- cell-mediated immunity
- recognition of foreign peptides plus self
- antigen processing - role of MHC encoded molecules in the regulation of afferent immune responses
- perspectives from immune recognition of discontinuous sites
- protein-protein recognition
- experimental determination of immunogenic sites
- prediction of antigenic sites
- peptide synthesis
- peptide structure in solution
- biosynthesis of peptides via recombinant DNA
- the special problems of carbohydrate vaccines
- engineered viruses as vaccines
- idiotype vaccine strategies
- malaria vaccine development
- foot and mouth disease
- vaccination against viral hepatitis
- vaccines against AIDS
- influenza
- synthetic vaccines - poliovirus.
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