The cancer handbook

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Bibliographic Information

The cancer handbook

editor-in-chief, Malcolm R. Alison

John Wiley & Sons, c2007

2nd ed

  • v. 1
  • v. 2

Available at  / 18 libraries

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Note

Includes bibliographical references and index

Description and Table of Contents

Description

The Cancer Handbook provides a comprehensive overview of scientific and clinical information in cancer research and medicine (oncology). This area is one of the most intensively studied in biology and medicine, resulting in a huge amount of new information being published every year. This book summarizes and explains key facts and recent developments. It is aimed at a wide variety of readers who need easy access to knowledge concerning all major aspects of cancer biology, without too much clinical detail or specialist research material. The Cancer Handbook stands out from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment. As more and more laboratory research is applied to clinical management, e.g. the use of monoclonal antibodies as drugs, it is important that clinicians understand the aetiology of the disease and the molecular basis of the new therapeutic approaches. It is also important for laboratory scientists to appreciate the potential applications of their research and the practical issues involved in translating it to clinical practice. For this second edition, all the sections have been fully revised and updated, with new chapters addressing important topics that have gained prominence in recent years. New editors and authors have brought additional expertise to the project. For example, in the section on the Molecular and Cellular Basis of Cancer, there are new chapters on stem cells, epigenetics, and microRNAs, as well as chapters on the links between cancer and development and inflammation. In the Treatment section, the emphasis is now on multidisciplinary team management of different cancers, plus there are new chapters on clinical trial design, RNA interference and rational drug design. The page design and the quality of the diagrams has been improved, with all illustrations now in full colour. The glossary has been made more informative and easy to use.

Table of Contents

Part I The Molecular and Cellular Basis of Cancer 1 Cell and Tissue Organization 2 Stem Cells and Tumorigenesis 3 Regulation of the Cell Cycle, Cell Cycle Checkpoints, and Cancer 4 Apoptosis 5 Genetic Susceptibility to Cancer 6 The Role of Epigenetic Alterations in Cancer 7 Genomic Instability and DNA Repair 8 Micro-RNAs as Oncogenes and Tumour Suppressors 9 Regulation of Translation in Malignant Transformation 10 Human DNA Tumour Viruses 11 RNA Tumour Viruses 12 Invasion and Metastasis 13 Angiogenesis 14 The Biology of Tumour Stroma 15 The Links between Inflammation and Cancer 16 Telomerase 17 Signalling by Steroid Receptors 18 Signalling by Cytokines 19 Signalling by Tyrosine Kinases 20 Signaling by Ras and Rho GTPases 21 Wnt Signal Transduction 22 Transforming Growth Factor-s And Cancer 23 p53 Family Pathway in Cancer 24 The Retinoblastoma Tumour Suppressor 25 Development and Cancer- The HOX Gene Connection Part II The Causation and Prevention of Cancer 26 Epidemiology in the Identification of Cancer Causes 27 Mechanisms of Chemical Carcinogenesis 28 The Formation of DNA Adducts 29 Physical Causes of Cancer 30 Non-genotoxic Causes of Cancer 31 Infectious Agents and Cancer 32 Short-Term Testing for Genotoxicity 33 Cancer Bioassays 34 Molecular Epidemiology of Cancer and the Use of Biomarkers 35 Dietary Genotoxins and Cancer 36 Tobacco Use and Cancer 37 Occupational Causes of Cancer 38 Intervention and Chemoprevention of Cancer - Treatment of Carcinogenesis Part III Systematic Oncology 39 Introduction to the Diagnosis of Cancer 40 Skin 41 Oral Cavity and Major and Minor Salivary Glands 42 Respiratory System 43 Upper Gastrointestinal Tract 44 Lower Gastrointestinal Tract 45 Pancreas 46 Liver, Gallbladder, and Extrahepatic Bile Ducts 47 Endocrine Organs 48 Breast 49 Female Reproductive System 50 Urinary Tract 51 Male Genital Tract 52 Lymph Nodes 53 Blood and Bone Marrow: Myeloid Leukaemias and Related Neoplasms 54 Bones 55 Soft Tissues 56 Pleura and Peritoneum 57 Heart 58 Neuromuscular System 59 Eye and Ocular Adnexa 60 Ear 61 Unknown Primary Part IV Pre-clinical models for Human Cancer 62 Advantages and Limitations of Models for Cancer and Malignant Cell Progression 63 Basic Tissue and Cell Culture in Cancer Research 64 Transgenic Technology in the Study of Oncogenes and Tumour-Suppressor Genes 65 Genetic Models: A Powerful Technology for the Study of Cancer 66 Gene Knockouts in Cancer Research 67 Human Tumours in Animal Hosts 68 Mathematical Models of Cancer Growth and Development 69 Models for Tumour Growth and Differentiation 70 Models for Tumour Cell-Stromal Cell Interactions 71 Models for Angiogenesis 72 Models for Tumour Cell Adhesion and Invasion 73 Models for Tumour Cell-Endothelial Cell Interactions 74 Models for Tumour Metastasis 75 Models for Drug Development and Drug Resistance 76 Models for Immunotherapy and Cancer Vaccines 77 Models for Gene Therapy 78 Models for Breast Cancers 79 Models for Prostate Cancer 80 Models for Genitourinary Cancer - Hereditary Renal Carcinogenesis 81 Mouse Models for Gastrointestinal Carcinomas 82 Models for Liver Cancer 83 Models for Lymphoma 84 Models for Human Leukaemias 85 Models for Sarcomas 86 Models for Skin Cancer 87 Models for CNS Malignancies Part V The Treatment of Cancer 88 Conventional Chemotherapeutics 89 Rational Drug Design of Small Molecule Anticancer Agents: Preclinical Discovery 90 Rational Drug Design of Small Molecule Anticancer Agents: Early Clinical Development 91 Modern Approaches to Radiation Therapy 92 Gene and Viral Therapy 93 Cancer Vaccines 94 Antibody Therapy for Cancer 95 Anti-angiogenic and Anti-stromal Therapy 96 RNA Interference 97 Cancer Chemoprevention 98 Mechanisms and Management of Cancer Pain 99 Clinical Trial Design for Anticancer Therapies 100 Head and Neck Cancer 101 Melanoma 102 Antihormonal Therapy for Breast and Prostate Cancer 103 Collaborative Approach to Multidisciplinary Breast Cancer Care 104 Management of Haematological Malignancies 105 Multidisciplinary Team Management of Lung Cancer 106 Multidisciplinary Team Management of Gynaecological Cancers 107 Multidisciplinary Management of Genitourinary Malignancies 108 Multidisciplinary Team Management of Upper Gastrointestinal, Hepatic, Pancreatic, and Biliary Cancers 109 Multidisciplinary Team Management of Colorectal Cancer.

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